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  1. Article

    Open Access

    Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

    The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripher...

    M.Ángeles Bonache, Cristina Martín-Escura… in Scientific Reports (2020)

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  2. No Access

    Article

    2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

    Conveniently substituted 2-alkyl-2-carboxyazetidine amino acids have been incorporated into NGF and NT3 tetrapeptide sequences to investigate their utility as reverse turn inducers (γ- vs. β-turns). Despite th...

    José Luis Baeza, M. Ángeles Bonache, M. Teresa García-López… in Amino Acids (2010)