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  1. No Access

    Article

    RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response

    Chromosomal region 1p22 is deleted in ⩾20% of multiple myeloma (MM) patients, suggesting the presence of an unidentified tumor suppressor. Using high-resolution genomic profiling, we delimit a 58 kb minimal de...

    I J F Hofman, M van Duin, E De Bruyne, L Fancello, G Mulligan, E Geerdens… in Leukemia (2017)

  2. Article

    Open Access

    Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach

    M Went, A Sud, P J Law, D C Johnson, N Weinhold, A Försti… in Blood Cancer Journal (2017)

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  3. No Access

    Article

    Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease

    Deletion or mutation of the gene encoding the deubiquitinating enzyme CYLD is a common genomic aberration in multiple myeloma (MM). However, the functional consequence of CYLD loss and the mechanism underlying...

    H van Andel, K A Kocemba, A de Haan-Kramer, C H Mellink, M Piwowar, A Broijl… in Oncogene (2017)

  4. Article

    Open Access

    Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma

    While clinical benefit of the proteasome inhibitor (PI) bortezomib (BTZ) for multiple myeloma (MM) patients remains unchallenged, dose-limiting toxicities and drug resistance limit the long-term utility. The E...

    E Malek, M A Y Abdel-Malek, S Jagannathan, N Vad, R Karns, A G Jegga, A Broyl… in Leukemia (2017)

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  5. Article

    Open Access

    18F-fluoride-PET for dynamic in vivo monitoring of bone formation in multiple myeloma

    Bone disease in multiple myeloma is characterized by reduced bone formation. The gold standard of bone formation is the mineral apposition rate (MAR), an invasive technique reflecting bone formation at a singl...

    J. C. Regelink, P. G. Raijmakers, N. Bravenboer, R. Milek, N. J. Hoetjes… in EJNMMI Research (2016)

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  6. No Access

    Article

    Gene expression profile alone is inadequate in predicting complete response in multiple myeloma

    With advent of several treatment options in multiple myeloma (MM), a selection of effective regimen has become an important issue. Use of gene expression profile (GEP) is considered an important tool in predic...

    S B Amin, W-K Yip, S Minvielle, A Broyl, Y Li, B Hanlon, D Swanson, P K Shah… in Leukemia (2014)

  7. Article

    Erratum: A gene expression signature for high-risk multiple myeloma

    Correction to: Leukemia (2012) 26, 2406–2413; doi:10.1038/leu.2012.127 Since the publication of this article, the authors have discovered an error in the script for calculating the IFM-15 risk scores. In their...

    R Kuiper, A Broyl, Y de Knegt, M H van Vliet, E H van Beers, B van der Holt… in Leukemia (2014)

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  8. No Access

    Article

    A gene expression signature for high-risk multiple myeloma

    There is a strong need to better predict the survival of patients with newly diagnosed multiple myeloma (MM). As gene expression profiles (GEPs) reflect the biology of MM in individual patients, we built a pro...

    R Kuiper, A Broyl, Y de Knegt, M H van Vliet, E H van Beers, B van der Holt… in Leukemia (2012)

  9. Article

    Open Access

    Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix

    Human papillomaviruses (HPV) are strongly associated with cervical intraepithelial neoplasia (CIN) and invasive cancer mainly through the action of the E6 and E7 viral proteins, transcription of which is down-...

    A Giannoudis, M van Duin, P J F Snijders, C S Herrington in British Journal of Cancer (2001)

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  10. No Access

    Chapter

    Blends of polyamides and maleic-anhydride-containing polymers: interfacial chemistry and properties

    Mixing two or more polymers usually results in phase separated systems, although molecularly miscible polymer blends are known too, some of them having economic importance. Blends of immiscible polymers offer att...

    M. van Duin, R. J. M. Borggreve in Reactive Modifiers for Polymers (1997)

  11. No Access

    Chapter

    Isolation and Characterization of Genes Involved in Mammalian Excision Repair

    Repair of randomly occuring DNA injury in mammalian cells must require sophisticated and elaborative systems in view of the wide spectrum of different types of lesions that have to be recognized and removed, t...

    Jan H. J. Hoeijmakers, M. van Duin, M. Koken, A. Yasui… in DNA Damage and Repair (1989)

  12. No Access

    Article

    Molecular cloning of a human DNA repair gene

    Cell strains derived from patients having a hereditary disorder associated with defects in repair of DNA damage such as xeroderma pigmentosum1,2 and mutants isolated from established rodent cell lines3,4 provide ...

    A. Westerveld, J. H. J. Hoeijmakers, M. van Duin, J. de Wit, H. Odijk, A. Pastink… in Nature (1984)