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Article
Open AccessGECO: gene expression clustering optimization app for non-linear data visualization of patterns
Due to continued advances in sequencing technology, the limitation in understanding biological systems through an “-omics” lens is no longer the generation of data, but the ability to analyze it. Importantly, ...
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Elaboration of a Multispecies Model of Solid Tumor Growth with Tumor-Host Interactions
There has been increasing evidence of the critical effects of microenvironmental influence on tumor growth and metastasis. In this report, we extend a multispecies continuum model of solid tumor growth to incl...
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Article
A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer
Constitutive activation of the Wnt/β-catenin pathway has been implicated as the primary cause of colon cancer. However, the major transducers of Wnt signaling in the intestine, T-cell factor 1 (TCF-1) and TCF-...
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Article
Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling
Aberrant Wnt signaling mediated by mutations affecting APC (adenomatous polyposis coli) or β-catenin initiates the majority of human colorectal cancers (CRC) and drives tumorigenesis through the activation of spe...
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Article
Diversity of LEF/TCF action in development and disease
Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the nucleus by recruiting β-catenin and its co-activators to Wnt response elements (WREs) of target genes. This activity is import...
