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Schizophrenia: Shifting the balance of care
Schizophrenia poses a major challenge to policy makers in health and social care in England. As deinstitutionalisation has progressed, public concern about people with the condition has increased owing to a sm...
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Human adenosine A2a receptor (A2aAR) gene: systematic mutation screening in patients with schizophrenia
Several lines of evidence suggest an involvement of adenosine A2a receptor (A2aAR) mediated adenosinergic neuromodulation in the etiopathogenesis of schizophrenia. We therefore perfomed a systematic mutation scan...
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Article
QALYs and mental health care
Quality-adjusted life year measures (QALYs) have been fervently debated by researchers and decision makers concerned with resource allocation in the health care sector. They have been heralded as important aid...
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Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease
Several lines of evidence suggest a contribution of adenosinergic neurotransmission to the development of panic disorder. We therefore hypothesized that variation in the A1 and A2a adenosine receptor (AR) genes m...
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Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder
A possible dysregulation of dopaminergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses, in particular of paranoid-hallucinatory states, and of the manic episodes of bipolar...
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Article
Does a hostel's managing agency determine the access to psychiatric services of its residents?
This study examines the effect of managing agency (local authority, private or voluntary) on the use of other health and social care services by residents in mental health hostels and group homes with differe...
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Wirtschaftliche Evaluation der psychiatrischen Versorgung
Die enormen und anhaltenden persönlichen und sozialen Folgen psychischer Erkrankungen sind seit langem bekannt. Die Chronizität von Krankheiten wie Schizophrenic und Demenz und die zwar geringere, aber auch la...
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Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios
A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al1 using a case-control design with patients with...
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Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings
The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a c...
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DRD4 exon III VNTR polymorphism—susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach
Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.1 Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the...
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Dopamine D3 receptor variant and tardive dyskinesia
In the search for genetic factors contributing to tardive dyskinesia, dopamine receptor genes are considered major candidates. The dopamine D3 receptor is of primary interest as dopamine D3 receptor knock-out mi...
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Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1)
The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3′-...
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Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach
Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. The activity of COMT is known to vary within the populat...
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Economic Evaluation of Mental Health Care
There has long been recognition of the enormous and persistent personal and social consequences of mental illness. The chronicity of disorders such as schizophrenia and dementia, and the long-term if lower-lev...
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Article
Provision of services for people with schizophrenia in five European regions
Background: An increasing diversity of public, voluntary sector and private providers offer services for the mentally ill in the ongoing process of psychiatric reform. Good service description is...
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Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIα gene (PIP5K2A) with schizophrenia
Linkage studies in schizophrenia have identified a candidate region on chromosome 10p14–11 as reported for several independent samples. We investigated association of DNA sequence variants in a plausible candi...
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Open AccessGlobal patterns of workplace productivity for people with depression: absenteeism and presenteeism costs across eight diverse countries
Depression is a leading cause of disability worldwide. Research suggests that by far, the greatest contributor to the overall economic impact of depression is loss in productivity; however, there is very littl...
