25 Result(s)
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Open AccessAssociations of protein source, distribution and healthy dietary pattern with appendicular lean mass in oldest-old men: the Helsinki Businessmen Study (HBS)
To investigate how food and dietary intakes, protein daily distribution and source were associated with appendicular lean mass (ALM)/m2 in the oldest-old community-dwelling men.
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Increased Mortality Despite Successful Multifactorial Cardiovascular Risk Reduction in Healthy Men: 40-Year Follow-Up of the Helsinki Businessmen Study Intervention Trial
In a 5-year multifactorial risk reduction intervention for healthy men with at least one cardiovascular disease (CVD) risk factor, mortality was unexpectedly higher in the intervention than the control group d...
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Open AccessRepeated exposure to systemic inflammation and risk of new depressive symptoms among older adults
Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to a lack of regard for persistency of exposure. We examined whether being inflamed on multiple occasions ...
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Open AccessHealthy obesity and risk of accelerated functional decline and disability
Some obese adults have a normal metabolic profile and are considered ‘healthy’, but whether they experience faster ageing than healthy normal-weight adults is unknown. We compared decline in physical function,...
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Open AccessBody mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study
While many studies have shown associations between obesity and increased risk of morbidity and mortality, little comparable information is available on how body mass index (BMI) impacts health expectancy. We e...
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Depressive symptoms and obesity: instrumental variable analysis using mother–offspring pairs in the 1970 British Cohort Study
The extent to which depression and obesity are causally related remains to be determined. We used intergenerational data on mother–offspring pairs in an instrumental variable analysis to examine the longitudin...
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Article
Open AccessInsulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing
Depressive disorders are a leading cause of disability in older age. Although the role of psychosocial and behavioural predictors has been well examined, little is known about the biological origins of depress...
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Healthy obesity is not safe obesity
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Open AccessSarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing
We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults.
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Article
Open AccessJob strain and risk of obesity: systematic review and meta-analysis of cohort studies
Job strain, the most widely used indicator of work stress, is a risk factor for obesity-related disorders such as cardiovascular disease and type 2 diabetes. However, the extent to which job strain is related ...
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Article
Length of sick leave as a risk marker of hip fracture: a nationwide cohort study from Sweden
Sickness absence is a risk marker for future health outcomes, but no previous studies have examined its association with osteoporotic fractures in old age. The results of this prospective population-based coho...
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Article
Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies
The hypothesis of metabolically healthy obesity posits that adverse health effects of obesity are largely avoided when obesity is accompanied by a favorable metabolic profile. We tested this hypothesis with de...
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Conflicts Between Work and Family Life and Subsequent Sleep Problems Among Employees from Finland, Britain, and Japan
Research on the association between family-to-work and work-to-family conflicts and sleep problems is sparse and mostly cross-sectional. We examined these associations prospectively in three occupational cohorts.
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Open AccessLong-term inflammation increases risk of common mental disorder: a cohort study
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Effect of time of day and fasting duration on measures of glycaemia: analysis from the Whitehall II Study
We aimed to study diurnal variation in glucose regulation by examining the effects of time of day and fasting duration on fasting plasma glucose (FPG), 2 h post-load plasma glucose (2hPG) and HbA1c levels.
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Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
Meta-analysis of case–control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL, PTER, MAF and NPC1 genes.
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Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing
There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not a universal finding. This discordance might be ascribed to the existence of a ‘healthy ob...
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Bidirectional association between depression and obesity in middle-aged and older women
Although it has been hypothesized that the depression–obesity relation is bidirectional, few studies have addressed this hypothesis in a prospective setting. We aimed to examine the bidirectional relationship ...
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Open AccessAntidepressant drug use and future diabetes risk
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Article
Open AccessVariants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies
We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies.
