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Open AccessSocial network ties before and after retirement: a cohort study
Social networks are associated with individual’s health and well-being. Working life offers opportunities to create and maintain social networks, while retirement may change these networks. This study examined...
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Open AccessSocial relationships as predictors of extended employment beyond the pensionable age: a cohort study
The aim is to examine whether characteristics of social relationships predict extended employment beyond the pensionable age among Finnish public sector workers. The study population consisted of 4014 particip...
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Open AccessAssociations of protein source, distribution and healthy dietary pattern with appendicular lean mass in oldest-old men: the Helsinki Businessmen Study (HBS)
To investigate how food and dietary intakes, protein daily distribution and source were associated with appendicular lean mass (ALM)/m2 in the oldest-old community-dwelling men.
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Increased Mortality Despite Successful Multifactorial Cardiovascular Risk Reduction in Healthy Men: 40-Year Follow-Up of the Helsinki Businessmen Study Intervention Trial
In a 5-year multifactorial risk reduction intervention for healthy men with at least one cardiovascular disease (CVD) risk factor, mortality was unexpectedly higher in the intervention than the control group d...
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Open AccessEstimating sleep parameters using an accelerometer without sleep diary
Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic...
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Open AccessRepeated exposure to systemic inflammation and risk of new depressive symptoms among older adults
Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to a lack of regard for persistency of exposure. We examined whether being inflamed on multiple occasions ...
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Open AccessHealthy obesity and risk of accelerated functional decline and disability
Some obese adults have a normal metabolic profile and are considered ‘healthy’, but whether they experience faster ageing than healthy normal-weight adults is unknown. We compared decline in physical function,...
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Open AccessBody mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study
While many studies have shown associations between obesity and increased risk of morbidity and mortality, little comparable information is available on how body mass index (BMI) impacts health expectancy. We e...
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Depressive symptoms and obesity: instrumental variable analysis using mother–offspring pairs in the 1970 British Cohort Study
The extent to which depression and obesity are causally related remains to be determined. We used intergenerational data on mother–offspring pairs in an instrumental variable analysis to examine the longitudin...
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Open AccessInsulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing
Depressive disorders are a leading cause of disability in older age. Although the role of psychosocial and behavioural predictors has been well examined, little is known about the biological origins of depress...
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Healthy obesity is not safe obesity
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Open AccessSarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing
We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults.
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Open AccessJob strain and risk of obesity: systematic review and meta-analysis of cohort studies
Job strain, the most widely used indicator of work stress, is a risk factor for obesity-related disorders such as cardiovascular disease and type 2 diabetes. However, the extent to which job strain is related ...
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Length of sick leave as a risk marker of hip fracture: a nationwide cohort study from Sweden
Sickness absence is a risk marker for future health outcomes, but no previous studies have examined its association with osteoporotic fractures in old age. The results of this prospective population-based coho...
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Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies
The hypothesis of metabolically healthy obesity posits that adverse health effects of obesity are largely avoided when obesity is accompanied by a favorable metabolic profile. We tested this hypothesis with de...
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Open AccessIs personality associated with cancer incidence and mortality? An individual-participant meta-analysis of 2156 incident cancer cases among 42 843 men and women
The putative role of personality in cancer risk has been controversial, and the evidence remains inconclusive.
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Conflicts Between Work and Family Life and Subsequent Sleep Problems Among Employees from Finland, Britain, and Japan
Research on the association between family-to-work and work-to-family conflicts and sleep problems is sparse and mostly cross-sectional. We examined these associations prospectively in three occupational cohorts.
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Open AccessLong-term inflammation increases risk of common mental disorder: a cohort study
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Effect of time of day and fasting duration on measures of glycaemia: analysis from the Whitehall II Study
We aimed to study diurnal variation in glucose regulation by examining the effects of time of day and fasting duration on fasting plasma glucose (FPG), 2 h post-load plasma glucose (2hPG) and HbA1c levels.
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Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
Meta-analysis of case–control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL, PTER, MAF and NPC1 genes.