-
Article
Depressive symptoms and obesity: instrumental variable analysis using mother–offspring pairs in the 1970 British Cohort Study
The extent to which depression and obesity are causally related remains to be determined. We used intergenerational data on mother–offspring pairs in an instrumental variable analysis to examine the longitudin...
-
Article
Open AccessInsulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing
Depressive disorders are a leading cause of disability in older age. Although the role of psychosocial and behavioural predictors has been well examined, little is known about the biological origins of depress...
-
Article
Open AccessSarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing
We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults.
-
Article
Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies
The hypothesis of metabolically healthy obesity posits that adverse health effects of obesity are largely avoided when obesity is accompanied by a favorable metabolic profile. We tested this hypothesis with de...
-
Article
Open AccessIs personality associated with cancer incidence and mortality? An individual-participant meta-analysis of 2156 incident cancer cases among 42 843 men and women
The putative role of personality in cancer risk has been controversial, and the evidence remains inconclusive.
-
Article
Open AccessLong-term inflammation increases risk of common mental disorder: a cohort study
-
Article
Open AccessChildhood socioeconomic position, adult socioeconomic position and social mobility in relation to markers of adiposity in early adulthood: evidence of differential effects by gender in the 1978/79 Ribeirao Preto cohort study
Longitudinal studies drawn from high-income countries demonstrate long-term associations of early childhood socioeconomic deprivation with increased adiposity in adulthood. However, there are very few data fro...
-
Article
Is bipolar disorder more common in highly intelligent people? A cohort study of a million men
Anecdotal and biographical reports have long suggested that bipolar disorder is more common in people with exceptional cognitive or creative ability. Epidemiological evidence for such a link is sparse. We inve...
-
Article
Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing
There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not a universal finding. This discordance might be ascribed to the existence of a ‘healthy ob...
-
Article
Open AccessImpact of mental health problems on case fatality in male cancer patients
Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer.
-
Article
Resting heart rate and the risk of death and cardiovascular complications in patients with type 2 diabetes mellitus
An association between resting heart rate and mortality has been described in the general population and in patients with cardiovascular disease. There are, however, few data exploring this relationship in pat...
-
Article
Open AccessAntidepressant drug use and future diabetes risk
-
Article
Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study
Although clinical observations implicate cortisol in hypertension, the epidemiological evidence is less compelling. Little is known about the relationship between dehydroepiandrosterone sulphate (DHEAS) and hy...
-
Article
Oral disease and subsequent cardiovascular disease in people with type 2 diabetes: a prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial
While there are plausible biological mechanisms linking oral health with cardiovascular disease (CVD) and mortality rates, no study, to our knowledge, has examined this association in a representative populati...
-
Article
Obesity, overweight and liver disease in the Midspan prospective cohort studies
To analyse the relationship between body mass index (BMI) and liver disease in men and women.
-
Article
Obesity and overweight in relation to liver disease mortality in men: 38 year follow-up of the original Whitehall study
Obesity has been implicated in the aetiology of liver disease. However, to date, evidence is largely drawn from cross-sectional studies, where interpretation is hampered by reverse causality, and from studies ...
-
Article
Open AccessPost-challenge blood glucose concentration and stroke mortality rates in non-diabetic men in London: 38-year follow-up of the original Whitehall prospective cohort study
While individuals with diabetes have a raised risk of stroke, it is unclear whether hyperglycaemia in non-diabetic populations is related to the development of this disease.
-
Article
Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam Experience Study
We examined the relationship between pre-morbid intelligence quotient (IQ) and the metabolic syndrome, and assessed the role of the metabolic syndrome as a mediating factor in the association of IQ with total ...
-
Article
Childhood IQ in relation to obesity and weight gain in adult life: the National Child Development (1958) Study
To examine the relation of childhood intelligence (IQ) test results with obesity in middle age and weight gain across the life course.
-
Article
Obesity and overweight in relation to organ-specific cancer mortality in London (UK): findings from the original Whitehall study
To examine the relation of obesity and overweight with organ-specific cancer mortality.
