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Article
Hematopoietic Stem Cells: Uncomfortable Considerations
This report defines new concepts of hematopoietic stem cell biology.
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Article
A New View of Stem Cell Dynamics
Our understanding of the biology of hematopoietic stem cells is evolving beyond hierarchical models and markers of stem cell purification to a far more fluid model wherein degrees of multipotency of individual...
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Article
Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells
Mesenchymal stromal cells (MSCs) have been shown to reverse radiation damage to marrow stem cells. We have evaluated the capacity of MSC-derived extracellular vesicles (MSC-EVs) to mitigate radiation injury to...
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Chapter
Extracellular Vesicles and Tissue Organ Regeneration
Marrow cells are a rich source of vesicles (released from their surface or endosomal compartment that may deliver proteins, ribonucleic acid (RNA), and microRNA (miRNA) into damaged organs. Based on this, para...
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Article
The stem cell continuum
Traditional models of hematopoiesis have been hierarchical. Recent evidence showing that marrow stem cells are a cycling population and that the hematopoietic phenotype of these cells reversibly changes with c...
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Article
The marrow stem cell: the continuum
The marrow hematopoietic stem cell is currently being redefined as to all aspects of its phenotype and its total differentiation capacity. This redefinition now includes its plasticity as to production of nonh...
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Article
Stem cell engraftment and cell cycle phenotype
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Chapter and Conference Paper
Use of Visualisation and Qualitative Reasoning in Configuring Mechanical Fasteners
Fasteners products, used extensively throughout manufacturing industry for a diversity of applications (typically ‘inserts’ for joining together plastic assemblies), are supplied by an industry rich in terms o...
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Chapter
Representation and Manipulation of Fastener Knowledge
The fastener industry is rich in experiential knowledge, acquired over years from develo** a variety of fastener designs for a diverse range of applications. As such, the industry offers a prime target for k...
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Chapter
Conceptual Modelling to Evaluate the Flexibility Characteristics of Manufacturing Cell Designs
A conceptual model is being developed and implemented in a computer system to investigate the relationships between configurations of machine and cell design and the flexibility characteristics the designs exh...
