Abstract
Marrow cells are a rich source of vesicles (released from their surface or endosomal compartment that may deliver proteins, ribonucleic acid (RNA), and microRNA (miRNA) into damaged organs. Based on this, paracrine effects probably make major contributions in most of the currently reported positive results in clinical trials employing adult hematopoietic stem cells. In this chapter, we will discuss our data showing that extracellular vesicles might have significant therapeutic potential in various tissue injuries as well as in treatment of cancer.
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Quesenberry, P. et al. (2014). Extracellular Vesicles and Tissue Organ Regeneration. In: Ratajczak, M. (eds) Adult Stem Cell Therapies: Alternatives to Plasticity. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1001-4_14
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DOI: https://doi.org/10.1007/978-1-4939-1001-4_14
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