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Article
Open AccessIndividuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells
Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-di...
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Article
Open AccessThe Impact of Early-Stage Chronic Kidney Disease on Weight Loss Outcomes After Gastric Bypass
Weight loss achieved through bariatric metabolic surgery was demonstrated to be effective at reversing chronic kidney dysfunction associated with obesity-related glomerulopathy. However, robust data on how pre...
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Article
Open AccessAccuracy of prediction models for long-term type 2 diabetes remission after gastric bypass
To evaluate the accuracy of DiaBetter, DiaRem, Ad-DiaRem and 5y-Ad-DiaRem scores’ at predicting T2D remission 10 or more years after surgery.
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Article
Gastro-gastric Fistula: a Rare Complication of Gastric Banding
Gastric banding was a common procedure over the last decades, but, because of its poor results in weight loss and frequent complications, it has been avoided. A rare complication of this surgical technique is ...
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Article
Open AccessHow Sustained is Roux-en-Y Gastric Bypass Long-term Efficacy?
The rate of weight regain after Roux-en-Y Gastric Bypass (RYGB) can hamper the procedure long-term efficacy for obesity treatment and related comorbidities. To evaluate the rate of weight loss and comorbidity ...
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Article
Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?
There are no formal guidelines for choosing among different bariatric surgery procedures for obesity treatment. So, our aim was to evaluate whether post-absorptive metabolite and hormone profiles could aid the...
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Article
Gastric Bypass Improves Microvascular Perfusion in Patients with Obesity
Basic science research has shown that obesity is associated with microvascular endothelial dysfunction. However, whether bariatric surgery impacts the microvascular networks has yet to be explored. This study ...
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Article
Bariatric Surgery Induces Retinal Thickening Without Affecting the Retinal Nerve Fiber Layer Independent of Diabetic Status
Obese patients have neurodegeneration of the optic nerve demonstrated by decreased peripapillary nerve fiber layer. Whether bariatric surgery reverses this neurodegenerative process has not been explored. We a...
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Article
Different Malabsorptive Obesity Surgery Interventions Result in Distinct Postprandial Amino Acid Metabolomic Signatures
Biliopancreatic diversion with duodenal switch (BPD-DS) is an effective weight loss surgical procedure. Yet, BPD-DS is technically difficult to perform and carries a higher risk of nutrient deficiencies as com...
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Article
Open AccessUse of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and management
Our aim was to assess the potential of flash glucose monitoring (FGM) for diagnostic workup of suspected post-bariatric hypoglycaemia (PBH). Patients (N = 13) with suspected PBH underwent a food and symptoms d...
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Article
Does Reconstruction Type After Gastric Resection Matters for Type 2 Diabetes Improvement?
Gastrointestinal (GI) surgery involving gastric resection and bypass of intestinal segments was reported to facilitate glucose control in obese patients with type 2 diabetes (T2D).
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Article
Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles
Roux-en-Y gastric bypass (RYGB) with a long biliopancreatic limb (BPL) was demonstrated to further improve type 2 diabetes (T2D) outcomes. Whether benefits occur at the cost of a negative impact on nutrient ab...
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Article
Insights from the Impact of Meal Composition on Glucose Profile Towards Post-bariatric Hypoglycemia Management
The need to improve post-bariatric hypoglycemia (PBH) diagnosis and clinical management is well recognized. Our aim was to evaluate the influence of meal nutritional composition on interstitial fluid glucose (...
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Article
Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles
Biliopancreatic diversion with duodenal switch (BPD-DS) is the most effective bariatric intervention to treat morbid obesity and related disorders. Single-anastomosis duodeno-ileal bypass with sleeve gastrecto...
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Article
Retinal Nerve Fiber Layer Thickness Decrease in Obesity as a Marker of Neurodegeneration
Idiopathic intracranial hypertension (IIH) is a serious condition that is frequently associated with irreversibly vision loss, having a higher incidence among obese women. Our aims were to screen subclinical I...
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Article
Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb
Changes in gut hormone secretion are important for the anti-diabetic effects of bariatric surgery. Roux-en-Y gastric bypass (RYGB) with extended biliopancreatic limb (BPL) length may improve the metabolic outc...
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Article
Open AccessExcess body mass index loss predicts metabolic syndrome remission after gastric bypass
Metabolic syndrome (MS) is a condition associated with obesity that identifies individuals with increased cardiovascular risk. Gastric bypass improves several MS components, such as glucose, lipid metabolism a...
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Article
Open AccessHeterotopic pancreas in excluded stomach diagnosed after gastric bypass surgery
Heterotopic pancreas is defined as finding of pancreatic tissue without anatomic and vascular continuity with the normal pancreas. Heterotopic pancreas is a rare condition difficult to diagnose and with contro...
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Article
Sleeve Gastrectomy and Gastric Plication in the Rat Result in Weight Loss with Different Endocrine Profiles
Restrictive bariatric surgery procedures currently used include adjustable gastric banding, sleeve gastrectomy (SG), and gastric plication (GP), of which the last two techniques still lack sufficient data and ...
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Article
Metabolic Laparoscopic Gastric Bypass for Obese Patients with Type 2 Diabetes
Bariatric surgery has been proposed as the most effective treatment for patients with type 2 diabetes mellitus (T2DM) and body mass index (BMI) above 35 kg/m2. The purpose of our study was to access remission rat...
