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Article
Demonstrating responsiveness of the pediatric cardiac quality of life inventory in children and adolescents undergoing arrhythmia ablation, heart transplantation, and valve surgery
Pediatric Cardiac Quality of Life Inventory (PCQLI) is a disease-specific pediatric cardiac health-related quality of life (HRQOL) instrument that is reliable, valid, and generalizable. We aim to demonstrate P...
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Article
Carvedilol Does Not Improve Exercise Performance in Fontan Patients: Results of a Crossover Trial
Increased circulating catecholamines are associated with worse exercise performance in adult heart failure patients. Patients with Fontan physiology have increased circulating catecholamines and theoretically ...
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Article
Exercise Capacity and Predictors of Performance After Fontan: Results from the Pediatric Heart Network Fontan 3 Study
Impaired exercise following Fontan is a surrogate of morbidity. Single-center longitudinal data exist, but there is a lack of contemporary multi-center data. Ramp cycle ergometry was re-performed in consented ...
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Article
Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome
Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and refe...
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Article
The Relationship of Patient Medical and Laboratory Characteristics to Changes in Functional Health Status in Children and Adolescents After the Fontan Procedure
Despite hypothesized concerns about deterioration beginning in adolescence, longitudinal data and associated factors regarding standardized assessment of physical functioning are not available for Fontan patie...
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Article
Open AccessThe impact of socio-economic status on health related quality of life for children and adolescents with heart disease
Socioeconomic status (SES) is known to influence children’s health-related quality of life. Many SES indicators assess distinct dimensions of a family’s position rather than measuring the same underlying const...
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Article
External validity of the pediatric cardiac quality of life inventory
The Pediatric Cardiac Quality of Life Inventory (PCQLI) is a disease-specific, health-related quality of life (HRQOL) measure for pediatric heart disease (HD). The purpose of this study was to demonstrate the ...
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Article
Maturation of Calcium Transport in Cardiac Sarcoplasmic Reticulum
ABSTRACT: Developmental changes in myocardial function have been described by a number of investigators. To further define the cellular basis for these changes, the present study was designed to characterize a...
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Article
SEPARATION OF CARDIAC SARCOPLASMIC RETICULUM FROM FETAL AND MATERNAL SHEEP INTO FREE AND JUNCTIONAL SUBPOPULATIONS
We have previously shown decreased Ca accumulation in crude cardiac sarcoplasmic reticulum (SR) vesicles isolated from fetal sheep. However, recent data indicate that the cardiac SR is subspecialized and that ...
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Article
117 INCREASED CALCIUM CHANNEL DENSITY IN CARDIAC SARCOPLASMIC RETICULUM FROM FETAL SHEEP
Decreased active Ca accumulation by vesicles of cardiac sarcoplasmic reticulum (SR) from fetal sheep can in part be attributed to decreased density of Ca pumps. To determine if differences in Ca release channe...
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Article
DECREASED CONTRACTILITY OF THE DUCTUS ARTERIOSUS IN EXPERIMENTAL PULMONIC STENOSIS
Delayed closure of the ductus arteriosus (DA) after birth has been observed in newborn infants with critical pulmonic stenosis (PS) and in lambs with experimental PS. This delayed closure may be the result of ...
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Article
INDOMETHACIN THERAPY ON THE FIRST DAY OF LIFE IN VERY-LOW-BIRTHWEIGHT INFANTS
It has recently been suggested that early treatment with indomethacin(indo) of premature infants with asymptomatic heart murmurs decreased morbidity since the majority of these infants develop hemodynamically ...
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Article
INCREASED CALCIUM PUMP TURNOVER RATE IN CARDIAC SARCOPLASMIC RETICULUM IN FETAL SHEEP
We have previously reported decreased Ca uptake and Ca-dependent ATP hydrolysis in cardiac sarcoplasmic reticulum (SR) vesicles isolated from fetal sheep as compared to SR vesicles from maternal sheep. These i...
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Article
270 EXOGENOUS ARACHIDONIC ACID IS NOT CONVERTED TO PROSTAGLANDIN E2 BY THE LAMB DUCTUS ARTERIOSUS
Prostaglandin (PG) E2 regulates the patency of the ductus arteriosus (DA) in the fetus and preterm neonate. Numerous investigators have used exogenous arachidonic acid (aa), a precursor of PG synthesis, to study ...
