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Article
Open AccessWithin-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives ...
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Article
Open AccessGenetic association study of childhood aggression across raters, instruments, and age
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childh...
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Article
Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity
We conducted whole-genome sequencing of four inbred mouse strains initially selected for high (H1, H2) or low (L1, L2) open-field activity (OFA), and then examined strain distribution patterns for all DNA vari...
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Article
Characterization of a large sex determination region in Salix purpurea L. (Salicaceae)
Dioecy has evolved numerous times in plants, but heteromorphic sex chromosomes are apparently rare. Sex determination has been studied in multiple Salix and Populus (Salicaceae) species, and P. trichocarpa has an...
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Article
Narrow-sense heritability estimation of complex traits using identity-by-descent information
Heritability is a fundamental parameter in genetics. Traditional estimates based on family or twin studies can be biased due to shared environmental or non-additive genetic variance. Alternatively, those based...
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Article
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits
Multiple methods have been developed to estimate narrow-sense heritability, h2, using single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive evaluation of these methods has not ...
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Article
Using partitioned heritability methods to explore genetic architecture
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Article
Phenotypic and Genetic Relationship Between BMI and Drinking in a Sample of UK Adults
The health impairments derived from both alcoholism and obesity are well known. However, reports that relate increased alcohol use with increased measures of obesity have been mixed in their findings, especial...
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Article
Open AccessHigh-resolution genetic map** of allelic variants associated with cell wall chemistry in Populus
QTL cloning for the discovery of genes underlying polygenic traits has historically been cumbersome in long-lived perennial plants like Populus. Linkage disequilibrium-based association map** has been proposed ...
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Article
Population genomics of Populus trichocarpa identifies signatures of selection and adaptive trait associations
Stephen DiFazio and colleagues report the genome sequences and population genomic analyses of 544 black cottonwood trees (Populus trichocarpa) along the Northwest coast of North America. They find evidence for cl...
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Article
Herbivore host-associated genetic differentiation depends on the scale of plant genetic variation examined
Herbivore adaptation to plant genetic variation can lead to reproductive isolation and the formation of host-associated lineages (host-associated differentiation, or HAD). Plant genetic variation exists along ...
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Article
Populus hybrid hosts drive divergence in the herbivorous mite, Aceria parapopuli: implications for conservation of plant hybrid zones as essential habitat
Plant hybrid zones receive little conservation attention, yet they may be centers of diversity and evolutionary opportunity for dependent species. In previous studies, cottonwood hybrid zones have been shown t...
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Article
The relative influences of host plant genotype and yearly abiotic variability in determining herbivore abundance
Both plant genotype and yearly abiotic variation affect herbivore population sizes, but long-term data have rarely been used to contrast the relative contributions of each. Using a hierarchical Bayesian model,...
