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Chapter
Clinicopathologic Overview of Melanoma
Human melanoma is the most rapidly increasing malignant skin disease in Caucasians (Siegel et al. 2015). Once considered a rare disease, the lifetime risk for develo** melanoma in the US has increased from a...
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Article
Open AccessPotential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal ...
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Chapter
Introduction
Human melanoma is the most rapidly increasing malignant skin disease in Caucasians (Leiter and Garbe 2008). Once considered a rare disease, the lifetime risk for develo** melanoma in the US has increased fro...
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Chapter
Lessons from Embryogenesis
The plastic phenotype of aggressive melanoma has presented a significant challenge in the detection and targeting of tumor cells exhibiting stem cell-like characteristics. As the molecular signaling pathways u...
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Article
ErbB/EGF Signaling and EMT in Mammary Development and Breast Cancer
Activation of the ErbB family of receptor tyrosine kinases via cognate Epidermal Growth Factor (EGF)-like peptide ligands constitutes a major group of related signaling pathways that control proliferation, sur...
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Chapter
Plasticity Underlying Multipotent Tumor Stem Cells
Aggressive cancer cells manifest stem-cell-like qualities that allow them to self-renew and to derive a heterogeneous tumor. Ultimately, this multipotent phenotype facilitates metastasis and resistance to ther...
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Chapter
Role of the EGF-CFC Family in Mammary Gland Development and Neoplasia
Members of the Epidermal Growth Factor-Cripto-1/FRL-1/Cryptic (EGF-CFC) family, such as human Cripto-1, are important mediators of crucial events that take place during embryonic pattern formation. New evidenc...
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Chapter
Expression and prognostic significance of the EGFR in solid tumors
The epidermal growth factor receptor (EGFR) is expressed in the majority of human carcinomas, where it regulates proliferation and survival of cancer cells. Clinical studies have failed, however, to demonstrat...
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Chapter
Breast and Colon Carcinomas: Detection with Plasma CRIPTO-1
Human Cripto-1 (CR-1), also known as teratocarcinoma-derived growth factor-1 (TDGF-1) is a member of the Epidermal Growth Factor (EGF)-Cripto-1/FRL-1/Cryptic (CFC) protein family (Bianco et al., 2005a; Strizzi et...
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Article
Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis
It is increasingly evident that genes known to perform critical roles during early embryogenesis, particularly during stem cell renewal, pluripotentiality and survival, are also expressed during the developmen...
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Article
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-β signaling
We present evidence that Notch4ICD attenuates TGF-β signaling. Cells expressing the activated form of the Notch4 receptor (ICD4) were resistant to the growth-inhibitory effects of TGF-β. Notch4ICD was found to bi...
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Article
Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma
Human Cripto-1 (CR-1) is overexpressed in approximately 80% of human breast, colon and lung carcinomas. Mouse Cr-1 upregulation is also observed in a number of transgenic (Tg) mouse mammary tumors. To determin...
