31 Result(s)
within
Elisabeth A. Seftor
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Chapter
Heterogeneity of Melanoma with Stem Cell Properties
Metastatic melanoma continues to present a significant challenge—with a cure rate of less than 10% and a median survival of 6–9 months. Despite noteworthy advances in the field, the heterogeneity of melanoma t...
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Article
Targeting the Stem Cell Properties of Adult Breast Cancer Cells: Using Combinatorial Strategies to Overcome Drug Resistance
Cancer is a major public health problem worldwide. In aggressive cancers, which are heterogeneous in nature, there exists a paucity of targetable molecules that can be used to predict outcome and response to t...
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Article
Open AccessVasculogenic mimicry in small cell lung cancer
Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing v...
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Plasticity underlies tumor progression: role of Nodal signaling
The transforming growth factor beta (TGFβ) superfamily member Nodal is an established regulator of early embryonic development, with primary roles in endoderm induction, left-right asymmetry, and primitive str...
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Maspin: molecular mechanisms and therapeutic implications
Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Among the established anti-tumor effects of Maspin are ...
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Article
Open AccessPotential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal ...
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Lessons from Embryogenesis
The plastic phenotype of aggressive melanoma has presented a significant challenge in the detection and targeting of tumor cells exhibiting stem cell-like characteristics. As the molecular signaling pathways u...
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Open AccessMicroenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of...
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Overview of Tumor Cells and the Microenvironment
The bidirectional communication between cells and their microenvironment is integral to both cancer progression and embryological development. This chapter illuminates major breakthroughs in our understanding ...
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Plasticity Underlying Multipotent Tumor Stem Cells
Aggressive cancer cells manifest stem-cell-like qualities that allow them to self-renew and to derive a heterogeneous tumor. Ultimately, this multipotent phenotype facilitates metastasis and resistance to ther...
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Article
Open AccessThe Epigenetic Influence of Tumor and Embryonic Microenvironments: How Different are They?
The microenvironment is being increasingly recognized as a critical component in tumor progression and metastases. As such, the bi-directional signaling of extracellular mediators that promote tumor growth wit...
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Article
Reprogramming metastatic tumour cells with embryonic microenvironments
Aggressive tumour cells, such as melanoma, share many characteristics with embryonic progenitors, which contribute to the conundrum of tumour cell plasticity. ...
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Article
Exploiting the Convergence of Embryonic and Tumorigenic Signaling Pathways to Develop New Therapeutic Targets
As our understanding of embryonic stem cell biology becomes more sophisticated, the similarities between multipotent cancer cells and these totipotent precursors are increasingly striking. Both multipotent can...
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Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity
Tumor cell plasticity poses a significant clinical challenge in that the fate and function of tumor cells can be elusive until a tumor mass is evident. An overview of key molecular events in prostate cancer, i...
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Chapter
Vasculogenic Mimicry: Angiogenesis in Disguise?
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Chapter
The Plasticity of Melanoma Cells and Associated Clinical Implications
The molecular signature of aggressive cutaneous and uveal melanoma cells is consistent with an undifferentiated cell with a genetic profile similar to that of embryonic cells. The associated plastic phenotype ...
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Article
Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
The molecular 'signature' of aggressive melanoma cells is illustrative of an undifferentiated cell with a gene-expression profile that is similar to that of em...
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Article
Molecular plasticity of human melanoma cells
The molecular analysis of tumors, such as melanoma, has benefited significantly from microarray technology that can facilitate the classification of tumors based on the differential expression of genes. The da...
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Article
Molecular determinants of human uveal melanoma invasion and metastasis
The molecular analysis of cancer has benefited tremendously from the sequencing of the human genome integrated with the science of bioinformatics. Microarray analysis technology has the potential to classify t...
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Protocol
Membrane Invasion Culture System
Metastasis is the major cause of morbidity and death for cancer patients. A critical challenge to clinical and basic scientists is the development of improved prognostic methods to predict the metastatic aggre...
