545 Result(s)

Article

Lipidomic signatures in patients with early-onset and late-onset Preeclampsia

Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with ...

Yu Huang, Qiaoqiao Sun, Beibei Zhou, Yiqun Peng, **gyun Li, Chunyan Li… in Metabolomics (2024)

Article

Lipidomics random forest algorithm of seminal plasma is a promising method for enhancing the diagnosis of necrozoospermia

Despite the clear clinical diagnostic criteria for necrozoospermia in andrology, the fundamental mechanisms underlying it remain elusive. This study aims to profile the lipid composition in seminal plasma syst...

Tianqin Deng, Wanxue Wang, Zhihong Fu, Yuli **e, Yonghong Zhou, Jiangbo Pu… in Metabolomics (2024)

Article

Characterizing human postprandial metabolic response using multiway data analysis

Analysis of time-resolved postprandial metabolomics data can improve our understanding of the human metabolism by revealing similarities and differences in postprandial responses of individuals. Traditional da...

Shi Yan, Lu Li, David Horner, Parvaneh Ebrahimi, Bo Chawes… in Metabolomics (2024)

Article

4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara

Cardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis patients was positively associated to mortality. It is important to look for d...

Yuanqun Zhou, Yu Zhu, Yue Wu, **nming **ang, **ngnan Ouyang, Liangming Liu… in Metabolomics (2024)

Article

Plasma and serum metabolic analysis of healthy adults shows characteristic profiles by subjects’ sex and age

Pre-analytical factors like sex, age, and blood processing methods introduce variability and bias, compromising data integrity, and thus deserve close attention.

Rui Xu, Shiqi Zhang, Jieli Li, Jiangjiang Zhu in Metabolomics (2024)

Article

The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6

Transcriptional repressor B cell lymphoma 6 (Bcl6) is a major transcription factor involved in Tfh cell differentiation and germinal center response, which is regulated by a variety of biological processes. Ho...

**gtian Guo, Yimeng Wang, Lei Tang, Tiejun Tang, Zhuolan Li, Mengyuan Li… in Chromosoma (2023)

Article

Metabolomic profiling of preterm birth in pregnant women living with HIV

Preterm birth is a leading cause of death in children under the age of five. The risk of preterm birth is increased by maternal HIV infection as well as by certain antiretroviral regimens, leading to a disprop...

Nicole H. Tobin, Aisling Murphy, Fan Li, Sean S. Brummel, Mary Glenn Fowler… in Metabolomics (2023)

Article

OME-Zarr: a cloud-optimized bioimaging file format with international community support

A growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by the Open Microscopy Environment (OME), individuals an...

Josh Moore, Daniela Basurto-Lozada, Sébastien Besson… in Histochemistry and Cell Biology (2023)

Article

MicroRNA-598 inhibition ameliorates LPS-induced acute lung injury in mice through upregulating Ebf1 expression

Acute lung injury is a critical acute respiratory distress syndrome (ARDS) with high morbidity and mortality. MicroRNAs (miRNAs) have been demonstrated to play important roles regulating acute lung injury deve...

Qi Zhao, Lei He, Junwu Zhang, Hong Li, Wanying Li… in Histochemistry and Cell Biology (2023)

Article

TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation

Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic defects. The genotype–phenotype correlation of this disease has been reported poorly. He...

Yuqing Guan, **ongda Liang, Wei Li, Wanying Lin, Guanxia Liang… in Skeletal Muscle (2023)

Article

Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers

Two of the most lethal gastrointestinal (GI) cancers, gastric cancer (GC) and colon cancer (CC), are ranked in the top five cancers that cause deaths worldwide. Most GI cancer deaths can be reduced by earlier ...

Guodong Song, Li Wang, Junlong Tang, Haohui Li, Shuyu Pang, Yan Li, Li Liu… in Metabolomics (2023)

Article

Correction to: Gonadal mosaicism mediated female-biased gender control in mice

Meizhu Bai, Dan Liang, Yan Cheng, Guolong Liu, Qiudao Wang, **song Li… in Protein & Cell (2022)

Article

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular immune responses in different organs, remains elusive. In th...

Chun-Chun Gao, Man Li, Wei Deng, Chun-Hui Ma, Yu-Sheng Chen… in Protein & Cell (2022)

Article

Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture

Although widely applied in treating hematopoietic malignancies, transplantation of hematopoietic stem/progenitor cells (HSPCs) is impeded by HSPC shortage. Whether circulating HSPCs (cHSPCs) in steady-state bl...

Yulin Xu, **angjun Zeng, Mingming Zhang, Binsheng Wang, **n Guo, Wei Shan… in Protein & Cell (2022)

Article

Postnatal state transition of cardiomyocyte as a primary step in heart maturation

Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine. While static snapshots of the maturing heart have provided much in...

Zheng Li, Fang Yao, Peng Yu, Dandan Li, Mingzhi Zhang, Lin Mao… in Protein & Cell (2022)

Article

Tsai Chiao: The founder of physiology and aviation, aerospace and navigation medicine in China

Yalan Wang, Zijian Li, Yanyan Qian, Benyu Guo in Protein & Cell (2022)

Article

Gonadal mosaicism mediated female-biased gender control in mice

Meizhu Bai, Dan Liang, Yan Cheng, Guolong Liu, Qiudao Wang, **song Li… in Protein & Cell (2022)

Article

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

In the original publication the author’s name ‘Dimitri Lavillete’ is published incorrectly. The correct author name should be spelt as ‘Dimitri Lavillette’ is provided in this correction.

Rui **ong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang… in Protein & Cell (2022)

Article

New pathogenic insights from large animal models of neurodegenerative diseases

Animal models are essential for investigating the pathogenesis and develo** the treatment of human diseases. Identification of genetic mutations responsible for neurodegenerative diseases has enabled the cre...

Peng Yin, Shihua Li, **ao-Jiang Li, Weili Yang in Protein & Cell (2022)

Article

Darwinian rebel: The legacy of Loh-Seng Tsai—Chinese animal psychologist

Yong Wang, Wei Chen, Shiying Li, Bin Yin in Protein & Cell (2022)