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Article
Open AccessMetabolomic profiling of preterm birth in pregnant women living with HIV
Preterm birth is a leading cause of death in children under the age of five. The risk of preterm birth is increased by maternal HIV infection as well as by certain antiretroviral regimens, leading to a disprop...
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Article
Comparison of dried blood spot and plasma sampling for untargeted metabolomics
Untargeted metabolomics holds significant promise for biomarker detection and development. In resource-limited settings, a dried blood spot (DBS)-based platform would offer significant advantages over plasma-b...
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Article
Open AccessAlterations to the Gastrointestinal Microbiome Associated with Methamphetamine Use among Young Men who have Sex with Men
Methamphetamine (MA) use is a major public health problem in the United States, especially among people living with HIV (PLWH). Many MA-induced neurotoxic effects are mediated by inflammation and gut microbiot...
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Article
Open AccessQuantification of variation and the impact of biomass in targeted 16S rRNA gene sequencing studies
Recent advances in sequencing technologies and bioinformatics tools have allowed for large-scale microbiome studies that are rapidly advancing medical research. However, small changes in technique or analysis ...
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Article
Open AccessBreast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures
Mother-to-child transmission of human immunodeficiency virus-type 1 (HIV-1) poses a serious health threat in develo** countries, and adequate interventions are as yet unrealized. HIV-1 infection is frequentl...
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Article
Are Infants Unique in Their Ability to be “Functionally Cured” of HIV-1?
The recent report of an infant that appears to have achieved a “functional cure” of HIV-1 following receipt of antiretroviral therapy (ART) within 30 hours of birth raises many questions: was the child infecte...
