-
Article
Open AccessCharacterizing human postprandial metabolic response using multiway data analysis
Analysis of time-resolved postprandial metabolomics data can improve our understanding of the human metabolism by revealing similarities and differences in postprandial responses of individuals. Traditional da...
-
Article
Open AccessAnalyzing postprandial metabolomics data using multiway models: a simulation study
Analysis of time-resolved postprandial metabolomics data can improve the understanding of metabolic mechanisms, potentially revealing biomarkers for early diagnosis of metabolic diseases and advancing precisio...
-
Article
The infant gut virome is associated with preschool asthma risk independently of bacteria
Bacteriophage (also known as phage) communities that inhabit the gut have a major effect on the structure and functioning of bacterial populations, but their roles and association with health and disease in ea...
-
Article
Open AccessNo associations between type 1 diabetes and atopic dermatitis, allergic rhinitis, or asthma in childhood: a nationwide Danish case-cohort study
Studies examining the association between type 1 diabetes (T1D) and atopic diseases, i.e., atopic dermatitis, allergic rhinitis and asthma have yielded conflicting results due to different algorithms for class...
-
Article
Open AccessThe airway microbiota of neonates colonized with asthma-associated pathogenic bacteria
Culture techniques have associated colonization with pathogenic bacteria in the airways of neonates with later risk of childhood asthma, whereas more recent studies utilizing sequencing techniques have shown t...
-
Article
Open AccessEuropean and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date...
-
Article
Open AccessHandgrip strength associates with effort-dependent lung function measures among adolescents with and without asthma
Studies have shown association between handgrip strength (HGS) and FEV1, but the importance of this in relation to asthma pathophysiology and diagnostics remains unclear. We investigated the relationship betwe...
-
Article
Open AccessExpanding known viral diversity in the healthy infant gut
The gut microbiome is shaped through infancy and impacts the maturation of the immune system, thus protecting against chronic disease later in life. Phages, or viruses that infect bacteria, modulate bacterial ...
-
Article
Time trends of chronic immune diseases by year of birth in Danish registries
Chronic immune diseases are often reported to be on the rise and are speculated to share early life risk factors. Here, we investigated year of birth as a common denominator for time trends using the consisten...
-
Article
Open AccessFUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically important disease entity through a genome-wide associat...
-
Article
Open AccessPrenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial
Maternal dietary interventions during pregnancy with fish oil and high dose vitamin D have been shown to reduce the incidence of asthma and wheeze in offspring, potentially through microbial effects in pregnan...
-
Article
Open AccessLevels of Systemic Low-grade Inflammation in Pregnant Mothers and Their Offspring are Correlated
High sensitivity C-reactive protein (hs-CRP) is a marker of systemic low-grade inflammation and associated with chronic inflammatory diseases. It is unknown whether maternal and infant hs-CRP levels are correl...
-
Article
NKG2D gene variation and susceptibility to viral bronchiolitis in childhood
Genetic factors associated with bronchiolitis are inadequately characterized. We therefore inspected a selected subpopulation of our previous genome-wide association study (GWAS) of bronchiolitis for overlap w...
-
Article
Open Access4th Pediatric Allergy and Asthma Meeting (PAAM)
WORKSHOP 4: Challenging clinical scenarios (CS01–CS06)
-
Article
Objective assessment of levels and patterns of physical activity in preschool children
The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity.
-
Article
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Lavinia Paternoster and colleagues report a meta-analysis of genome-wide association studies of atopic dermatitis. They report three newly identified associated loci near OVOL1 and ACTL9 and in KIF3A.
