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31 Result(s)
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Lu**g Li
English
Biochemistry, general
Human Genetics
Molecular Medicine
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Book
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Chapter
DNA Methylation Analysis Reveals a Strong Connection Between Tobacco Smoking and Cancer Pathogenesis
Tobacco smoking is a well-documented risk factor for various cancers, especially those of the lung. To test our hypothesis that abnormal DNA methylation loci associated with smoking are enriched in genes and p...
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Grand Challenges and Opportunities for Psychiatry, Including Nicotine Addiction Research
Psychiatric genetics is a new and promising field that may reveal what genetic variants are responsible for the development of a psychiatric disorder and enable customization of drug treatment for patients wit...
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Management, Pharmacotherapies, and Precision Medicine for Smoking Cessation
Although 70% of smokers want to quit, only 4–7% are successful in the long term. Cigarette smoking persists because of both the addictive propensity of nicotine and the low success rates of existing treatments...
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The Prevalence of Smoking and Its Associated Diseases
Smoking is the leading risk factor for several serious diseases and causes an enormous economic burden for the individual and society. Approximately six million deaths in the world annually are attributable to...
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Estimation of Genetic and Environmental Contributions to Smoking Addiction
Many studies of twins have shown that genetic and environmental factors play significant, and approximately equal, roles in the determination of smoking initiation (SI) and persistence (SP). Estimates of herit...
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Genetic Contribution of Variants in GABAergic Signaling to Nicotine Dependence
Although genetics contributes significantly to tobacco smoking, the susceptibility genes and variants underlying this behavior remain largely unknown. Genome-wide linkage and association studies have implicate...
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Significant Contribution of Variants in Serotonin Transporter and Receptor Genes to Smoking Dependence
Although genetics contributes significantly to smoking addiction, the susceptibility genes and variants underlying it remain largely unknown. Many years of genome-wide and candidate gene-based association stud...
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Background, Biology and Health Concerns of Electronic Cigarettes
Electronic cigarettes (ECIGs) are growing in popularity while generating worries on the part of lawmakers, healthcare providers, and smokers. Although ECIGs supposedly are a safe alternative to tobacco smoking...
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Addiction Genetics: Basic Concepts and Techniques
As in any other field in medicine, various technologies and analytical methods have been applied to study addictions and many other psychiatric disorders. To better understand the contents of this book and add...
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Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses
To identify susceptibility loci for smoking dependence, more than 20 genome-wide linkage studies have been conducted in different populations using a variety of nicotine dependence (ND) assessment approaches, ...
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Contribution of Variants in CHRNB3/A6 Gene Cluster on Chromosome 8 to Smoking Dependence
Nicotine, the primary addictive compound in tobacco, plays a vital role in the initiation and maintenance of its use. Nicotine exerts its pharmacological roles through nAChRs, which are ligand-gated ion channe...
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Neuroproteomics and Its Applications in Research on Nicotine and Other Drugs of Abuse
The rapidly growing field of neuroproteomics is able to track changes in protein expression and the protein modifications underlying various physiological conditions, including the neural diseases related to d...
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Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking andOther Addictions
Both nicotine and alcohol addictions are severe public health hazards worldwide. Various twin and family studies have demonstrated that genetic factors contribute to vulnerability to these addictions; however,...
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Tobacco Smoking, Food Intake, and Weight Control
Beyond promoting smoking initiation and preventing smokers from quitting, nicotine can reduce food intake and body weight and thus is seen as desirable by some smokers, perhaps especially women. During the las...
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Converging Findings from Linkage and Association Analyses on Susceptibility Genes for Smoking Addiction
To search for susceptibility genes and loci for nicotine addiction, many genetic approaches have been used, which include genome-wide linkage, candidate gene association, GWAS, and targeted sequencing. Through...
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Involvement of Variants in Gene Clusters CHRNA5/A3/B4 on Chromosome 15 to Smoking Behaviors and Lung Cancer
Nicotine exerts its physiological and pharmacological roles in the brain through neuronal nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels consisting of five membrane-spanning su...
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Identification of Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence, and Smoking Cessation
Twin and family studies reveal a significant genetic contribution to the risk of smoking initiation and progression (SI/P) and to ND and to the likelihood of smoking cessation (SC). Numerous genes have been im...
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Regulatory Roles of MicroRNAs in Addictions and Other Psychiatric Diseases
A central question in addiction is how drug-induced changes in synaptic signaling are converted into long-term neuroadaptations. Emerging evidence reveals that microRNAs (miRNAs) play a distinct role in this p...
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Nicotine Modulates Innate Immune Pathways via α7 Nicotinic Acetylcholine Receptor
Nicotine exerts its anti-inflammatory effects on multiple cell types and may benefit neurons in various degenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), in which an inflam...
