Page
%P
-
Article
Integrative analysis of genetics, epigenetics and RNA expression data reveal three susceptibility loci for smoking behavior in Chinese Han population
Despite numerous studies demonstrate that genetics and epigenetics factors play important roles on smoking behavior, our understanding of their functional relevance and coordinated regulation remains largely u...
-
Article
Open AccessAuthor Correction: CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies
-
Article
Open AccessCAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies
Immunotherapy utilizing chimeric antigen receptor T cell (CAR-T) therapy holds promise for hematologic malignancies, however, response rates and associated immune-related adverse effects widely vary among pati...
-
Article
Open AccessGenome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking
Smoking is a major causal risk factor for lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and is the main preventable cause of deaths in the world. The components of ci...
-
Article
Updated review of research on the gut microbiota and their relation to depression in animals and human beings
The gut microbiota are being called the human “second brain,” as they play a key role in the regulation of the central nervous system (CNS). Recent findings provide strong evidence for the presence of bidirect...
-
Article
Involvement of Interferon Regulatory Factor 7 in Nicotine’s Suppression of Antiviral Immune Responses
Nicotine, the active ingredient in tobacco smoke, suppresses antiviral responses. Interferon regulatory factors (IRFs) regulate transcription of type I interferons (IFNs) and IFN-stimulated genes (ISGs) in thi...
-
Article
Open AccessIdentification and characterization of SEC24D as a susceptibility gene for hepatitis B virus infection
Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion ...
-
Article
Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine’s Antidepressant Effect
Depression is a worldwide illness with a significant impact on both family and society. Conventional antidepressants are ineffective for more than 30% of patients. In such patients, who have what is called tre...
-
Article
Editors’ Commentary for Special Issue: The 2017 CALDAR Summer Institute and International Conference Promoting Global Health—Precision Research in Substance Abuse, HIV, and Care
This special issue contains 11 papers, including 3 Invited Reviews, one Brief Report and 6 Original Articles, which highlight the work by selected presenters at the third meeting of the biennial Conference Ser...
-
Article
Modulatory Effects of Nicotine on neuroHIV/neuroAIDS
Nicotine, one of the key active ingredients in tobacco smoke, exerts its effects via binding to nicotinic acetylcholine receptors (nAChRs). Although both negative and positive pharmacological effects of nicoti...
-
Article
Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control
Beyond promoting smoking initiation and preventing smokers from quitting, nicotine can reduce food intake and body weight and thus is viewed as desirable by some smokers, especially many women. During the last...
-
Article
Open AccessAssociation and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers
Variants in serotonergic genes are implicated in nicotine dependence (ND) in subjects of European and African origin, but their involvement with smoking in Asians is largely unknown. Moreover, mechanisms under...
-
Article
Implication of Genes for the N-Methyl-d-Aspartate (NMDA) Receptor in Substance Addictions
Drug dependence is a chronic brain disease with harmful consequences for both individual users and society. Glutamate is a primary excitatory neurotransmitter in the brain, and both in vivo and in vitro experi...
-
Article
Open AccessAssociation and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population
Nicotine dependence (ND) is a worldwide health problem. Numerous genetic studies have demonstrated a significant association of variants in nicotinic acetylcholine receptors (nAChRs) with smoking behaviors. Ho...
-
Book
-
Chapter
DNA Methylation Analysis Reveals a Strong Connection Between Tobacco Smoking and Cancer Pathogenesis
Tobacco smoking is a well-documented risk factor for various cancers, especially those of the lung. To test our hypothesis that abnormal DNA methylation loci associated with smoking are enriched in genes and p...
-
Chapter
Grand Challenges and Opportunities for Psychiatry, Including Nicotine Addiction Research
Psychiatric genetics is a new and promising field that may reveal what genetic variants are responsible for the development of a psychiatric disorder and enable customization of drug treatment for patients wit...
-
Chapter
Management, Pharmacotherapies, and Precision Medicine for Smoking Cessation
Although 70% of smokers want to quit, only 4–7% are successful in the long term. Cigarette smoking persists because of both the addictive propensity of nicotine and the low success rates of existing treatments...
-
Chapter
The Prevalence of Smoking and Its Associated Diseases
Smoking is the leading risk factor for several serious diseases and causes an enormous economic burden for the individual and society. Approximately six million deaths in the world annually are attributable to...
-
Chapter
Estimation of Genetic and Environmental Contributions to Smoking Addiction
Many studies of twins have shown that genetic and environmental factors play significant, and approximately equal, roles in the determination of smoking initiation (SI) and persistence (SP). Estimates of herit...
