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Book
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Chapter
Ascoviruses
The ascoviruses are an unclassified group of insect viruses that probably constitute a unique family of viruses. They possess a large [approximately 100 to 200 kilobase pairs (kbp)] DNA genome that is packaged...
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Article
Anti- and pro-apoptotic activities of baculovirus and Drosophila IAPs in an insect cell line
The anti-apoptotic activities of two baculovirus IAPs, OpIAP and CpIAP, were directly compared with that of two Drosophila IAPs, DIAP1 and DIAP2, in the same insect cell line, SF-21 cells. Like OpIAP and CpIAP, D...
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Article
Stable transformation of insect cells to coexpress a rapidly selectable marker gene and an inhibitor of apoptosis
We have constructed several plasmid expression vectors to express foreign genes in stably transformed insect cells. Unlike baculovirus-based expression vectors by which genes of interest are expressed transien...
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Book
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Chapter
Introduction to the Baculoviruses
Of all the viruses known to mankind, baculoviruses are the most beneficial from an anthropocentric viewpoint. While other viruses are studied because they cause problems, the basis of modern baculovirology was...
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Chapter
Regulation of Baculovirus Late and Very Late Gene Expression
The late stage of baculovirus infection is defined as those events that occur following the initiation of viral DNA replication and is usually subdivided into late and very late phases. These phases coincide w...
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Chapter
The Molecular Basis of Baculovirus Host Range
Because baculoviruses are currently important in a broad spectrum of biotechnologies ranging from biological pest control to gene expression vectors, an understanding of the molecular basis of the restriction ...
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Article
Expression of a Paralytic Neurotoxin Gene to Improve Insect Baculoviruses as Biopesticides
Recombinant baculoviruses expressing tox34, a mite gene encoding the insect–selective neurotoxin TxP–I, paralyze insects during the infection process. In this study, we investigated several key parameters which c...
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Article
Improvement of a Baculovirus Pesticide by Deletion of the EGT Gene
The egt gene of the insect baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) encodes the enzyme ecdysteroid UDP–glucosyltransferase. Expression of egt enables the virus to inhibit molting of ...
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Article
Insect paralysis by baculovirus-mediated expression of a mite neurotoxin gene
FEMALE mites of the species Pyemotes tritici inject an extremely potent venom into their insect prey that causes muscle-contraction and paralysis1–4. These mites are able to paralyse insects 150,000 times their ...
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Article
Viral proliferating cell nuclear antigen
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Chapter
An Insect Virus for Genetic Engineering: Develo** Baculovirus Polyhedrin Substitution Vectors
Baculoviruses are exceptionally attractive candidates as vectors for propagating and expressing exogenous DNAs in a eukaryotic (invertebrate) environment (Miller, 1981a). Among the features which make baculovi...
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Article
A virus mutant with an insertion of a copia-like transposable element
The important role insect viruses have in the biological control of pests has inspired a considerable effort towards understanding their molecular biology. The nuclear polyhedrosis viruses (NPVs) are particula...
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Article
Construction of infectious polyoma hybrid genomes in vitro
WITH recent advances in nucleic acid biochemistry, it has become possible to recombine different animal viral DNAs at specific sites in vitro1,2. Specific hybrid viral genomes can be used in the genetic analysis ...
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Article
Mutating and map** SV40
