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Article
Design and realization of lung organoid cultures for COVID-19 applications
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally and threatens public health. Advanced in vitro models that recapitulate the architecture and ...
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Article
Open AccessBiophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay between the biophysical tumor microenvironment and genetic regulation has significant impact on tumor progression. Especiall...
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Article
Interdependence among mental health care providers: evidence from a spatial dynamic panel data model with interactive fixed effects
Understanding the pricing and operation mechanism of community mental health (CMH) providers is important for designing effective health care policies as the CMH system has been playing an essential role in pr...
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Article
Open AccessTargeting Notch and EGFR signaling in human mucoepidermoid carcinoma
Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland cancers and patients with advanced, metastatic, and recurrent MECs have limited therapeutic options and poor treatment outcomes. MEC is ...
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Article
CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells
Mucoepidermoid carcinoma (MEC) arises in many glandular tissues and contributes to the most common malignant salivary gland cancers. MEC is specifically associated with a unique t(11;19) translocation and the ...
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Article
The Impact of Deep Sternal Wound Infection on Mortality and Resource Utilization: A Population-based Study
Recent national infection control efforts have been directed at reducing postsurgical infection rates, related morbidity, and cost. We sought to evaluate population-level rates of deep sternal wound infection...
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Article
Open AccessGene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells
Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with unresectable and metastatic MEC have poor long-term cl...
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Article
Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts
The Six1 homeoprotein belongs to the Six (sine oculis) transcription factor family, the members of which are known to act as master regulators of development. Six1 is essential for promoting myogenesis during mam...
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Article
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
Truncation of Notch1 has been shown to cause a subtype of acute leukemia1, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice2. Here we identify a new mechanism for di...
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Article
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs and humans1. In Drosophila melanogaster , loss-of-function mutations of Notch produce a 'neurogenic' phenotype in wh...
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Article
Role of the Ped Gene and Apoptosis Genes in Control of Preimplantation Development
Purpose: The properties of the mouse Ped gene and the genes that mediate apoptosis in mediating preimplantation embryonic survival were reviewed.
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Article
Sequence and transcription of Qa-2-encoding genes in mouse lymphocytes and blastocysts
The protein product of the mouse preimplantation embryo development (Ped) gene, which controls the rate of preimplantation embryonic cleavage division and subsequent embryo survival, is the Qa-2 antigen. This ma...
