15 Result(s)

Article

Structure of orthoreovirus RNA chaperone σNS, a component of viral replication factories

The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication compartments that support viral genome replication and capsid assembly. Despite its functional importance, a mechanis...

Boyang Zhao, Liya Hu, Soni Kaundal, Neetu Neetu… in Nature Communications (2024)

Article

A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity

Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwid...

Wilhelm Salmen, Liya Hu, Marina Bok, Natthawan Chaimongkol… in Nature Communications (2023)

Article

An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

β-lactamases inactivate β-lactam antibiotics leading to drug resistance. Consequently, inhibitors of β-lactamases can combat this resistance, and the β-lactamase inhibitory protein (BLIP) is a naturally occurr...

Shuo Lu, Liya Hu, Hanfeng Lin, Allison Judge, Paola Rivera… in Nature Communications (2022)

Article

Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity

Human noroviruses (HuNoVs) cause sporadic and epidemic viral gastroenteritis worldwide. The GII.4 variants are responsible for most HuNoV infections, and GII.4 virus-like particles (VLPs) are being used in vac...

Liya Hu, Wilhelm Salmen, Rong Chen, Yi Zhou, Frederick Neill… in Nature Communications (2022)

Article

Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Gabriela Alvarado, Wilhelm Salmen, Khalil Ettayebi, Liya Hu… in Nature Communications (2021)

Article

Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

The rational development of norovirus vaccine candidates requires a deep understanding of the antigenic diversity and mechanisms of neutralization of the virus. Here, we isolate and characterize a panel of bro...

Gabriela Alvarado, Wilhelm Salmen, Khalil Ettayebi, Liya Hu… in Nature Communications (2021)

Article

Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins

Prenylated indole alkaloids featuring spirooxindole rings possess a 3R or 3S carbon stereocenter, which determines the bioactivities of these compounds. Despite the stereoselective advantages of spirooxindole bio...

Zhiwen Liu, Fanglong Zhao, Boyang Zhao, Jie Yang, Joseph Ferrara… in Nature Communications (2021)

Article

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

TrkH is a bacterial ion channel implicated in K⁺ uptake and pH regulation. TrkH assembles with its regulatory protein, TrkA, which closes the channel when bound to ADP and opens it when bound to ATP. However, it ...

Hanzhi Zhang, Ya** Pan, Liya Hu, M. Ashley Hudson… in Nature Communications (2020)

Article

Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

Neonatal rotavirus infections are predominantly asymptomatic. While an association with gastrointestinal symptoms has been described in some settings, factors influencing differences in clinical presentation a...

Sasirekha Ramani, Christopher J. Stewart, Daniel R. Laucirica… in Nature Communications (2018)

Article

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the penicillin, cephalosporin and ‘last resort’ carbapenems, and thus confers bacterial resistance to nearly all β-lactam an...

Zhizeng Sun, Liya Hu, Banumathi Sankaran, B. V. Venkataram Prasad… in Nature Communications (2018)

Article

Glycan recognition in globally dominant human rotaviruses

Rotaviruses (RVs) cause life-threatening diarrhea in infants and children worldwide. Recent biochemical and epidemiological studies underscore the importance of histo-blood group antigens (HBGA) as both cell a...

Liya Hu, Banumathi Sankaran, Daniel R. Laucirica, Ketki Patil… in Nature Communications (2018)

Article

Multiple oligomeric structures of a bacterial small heat shock protein

Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformatio...

Nandini Mani, Spraha Bhandari, Rodolfo Moreno, Liya Hu… in Scientific Reports (2016)

Article

Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus

Strain-dependent variation of glycan recognition during initial cell attachment of viruses is a critical determinant of host specificity, tissue-tropism and zoonosis. Rotaviruses (RVs), which cause life-threat...

Liya Hu, Sasirekha Ramani, Rita Czako, Banumathi Sankaran, Ying Yu… in Nature Communications (2015)