32 Result(s)

Article

Proteomic profiling of gastric cancer with peritoneal metastasis identifies a protein signature associated with immune microenvironment and patient outcome

Peritoneal metastasis (PM) frequently occurs in patients with gastric cancer (GC) and is a major cause of mortality. Risk stratification for PM can optimize decision making in GC treatment.

Yanyan Chen, Guoxin Cai, Junjie Jiang, Chao He, Yiran Chen, Yongfeng Ding… in Gastric Cancer (2023)

Article

MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages

Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by qu...

Shuang Li, Dongyang Guo, Qiang Sun, Lu Zhang, Yun Cui… in Experimental & Molecular Medicine (2023)

Article

Microbiota and metabolites alterations in proximal and distal gastric cancer patients

Globally, gastric cancer is the third most common cancer and the third leading cause of cancer death. Proximal and distal gastric cancers have distinct clinical and biological behaviors. The microbial composit...

Yan Yang, Daofeng Dai, Wen **, Yingying Huang… in Journal of Translational Medicine (2022)

Article

m⁶Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation

PCIF1 (phosphorylated CTD interacting factor 1) is the first reported RNA N6,2′-O-dimethyladenosine (m⁶Am) methyltransferase. However, the pathological significance of PCIF1 and m⁶Am modification remains unknown....

Wei Zhuo, Meng Sun, Kun Wang, Lu Zhang, Kai Li, Danyang Yi, Mengjie Li… in Cell Discovery (2022)

Article

Host miRNAs-microbiota interactions in gastric cancer

It is widely acknowledged that gastric cancer seriously affects the quality of life and survival of patients. The correlation between the microbiota and gastric cancer has attracted extensive attention in rece...

Yan Yang, Yingying Huang, Wu Lin, ** Liu… in Journal of Translational Medicine (2022)

Article

Alterations of thyroid microbiota across different thyroid microhabitats in patients with thyroid carcinoma

In recent years, the incidence rate of Thyroid carcinoma (TC) has been increasing worldwide. Thus, research on factors of TC carcinogenesis may promote TC prevention and decrease the incidence rate. There are ...

Daofeng Dai, Yan Yang, Yong Yang, Tianfeng Dang… in Journal of Translational Medicine (2021)

Article

Interactions between gastric microbiota and metabolites in gastric cancer

The development and progression of gastric cancer (GC) is greatly influenced by gastric microbiota and their metabolites. Here, we characterized the gastric microbiome and metabolome profiles of 37 GC tumor ti...

Daofeng Dai, Yan Yang, Jieqing Yu, Tianfeng Dang, Wen**g Qin… in Cell Death & Disease (2021)

Article

Letter to the editor: new response evaluation criteria using early morphological change in imatinib treatment for patients with gastrointestinal stromal tumor

Junjie Jiang, Lisong Teng in Gastric Cancer (2021)

Article

Comment on: “Association between triglyceride-glucose index and gastric carcinogenesis: a health checkup cohort study. Gastric cancer, 2021 Aug 5” by Kim et al.

Junjie Jiang, Lisong Teng in Gastric Cancer (2021)

Article

A novel genomic classification system of gastric cancer via integrating multidimensional genomic characteristics

Gastric cancer (GC) is one of the leading causes of cancer deaths with high heterogeneity. There is currently a paucity of clinically applicable molecular classification system to guide precise medicine.

Haiyong Wang, Yongfeng Ding, Yanyan Chen, Junjie Jiang, Yiran Chen… in Gastric Cancer (2021)

Article

Coexistence of papillary thyroid carcinoma in secondary hyperparathyroidism

The coexistence of primary hyperparathyroidism and papillary thyroid carcinoma (PTC) is common and may be associative with more aggressive PTC, with higher rates of extrathyroidal extension and multicentricity...

Junhao Ma, Zhuochao Mao, Yun** Yao, Yimin Lu, Haohao Wang, Yan Yang… in BMC Surgery (2021)

Article

Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets

Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer. However, little is known about the genomic features of this disease. We perform whole-exome sequencing ...

Jun Lu, Yongfeng Ding, Yanyan Chen, Junjie Jiang, Yiran Chen… in Nature Communications (2021)

Article

Efficacy and safety of sintilimab in combination with chemotherapy in previously untreated advanced or metastatic nonsquamous or squamous NSCLC: two cohorts of an open-label, phase 1b study

Combining chemotherapy with immunotherapy improves the therapeutic outcome for first-line (1L) patients with advance nonsmall-cell lung cancer (NSCLC). Two cohorts of a phase 1b study (NCT02937116) aimed to ev...

Hai** Jiang, Yulong Zheng, Jiong Qian, Chenyu Mao… in Cancer Immunology, Immunotherapy (2021)

Article

SOX4 promotes the growth and metastasis of breast cancer

Increasing evidence has shown that the transcription factor SOX4 is closely associated with the development and progression of many malignant tumors. However, the effect of SOX4 on breast cancer is unclear. In...

**g Zhang, Chunhua **ao, Zhenbo Feng, Yun Gong, Baohua Sun… in Cancer Cell International (2020)

Article

Safety and efficacy of sintilimab combined with oxaliplatin/capecitabine as first-line treatment in patients with locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma in a phase Ib clinical trial

Sintilimab blocks the interaction between programmed death-1 (PD-1) and its ligands. The safety and efficacy of sintilimab combined with oxaliplatin/capecitabine (CapeOx) as first-line treatment were evaluated...

Hai** Jiang, Yulong Zheng, Jiong Qian, Chenyu Mao, **n Xu, Ning Li… in BMC Cancer (2020)