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  1. No Access

    Article

    Clonal analysis of early-stage bilateral papillary thyroid cancer identifies field cancerization

    Bilaterality is a newly identified indicator for aggressive tumor behavior and poor outcome in papillary thyroid cancer. However, the clonal origin of these bilateral tumors remains unclear.

    **ngyun Su, Shitu Chen, Kuifeng He, Zhuochao Mao, Jiaying Ruan, Jie Zhou… in Endocrine (2019)

  2. Article

    Open Access

    Establishment of patient-derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER-2, MET and FGFR2 signaling pathways

    Targeted therapies are emerging treatment options for gastric cancer (GC). Patient-derived tumor xenograft(PDX) models of GC closely retain the features of the original clinical cancer, offering a powerful too...

    Haiyong Wang, Jun Lu, Jian Tang, Shitu Chen, Kuifeng He, **aoxia Jiang… in BMC Cancer (2017)

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  3. Article

    Open Access

    Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer

    Aberrated activation of cMet in gastric cancer contributes to tumor growth, angiogenesis and metastasis. cMet-overexpressing gastric cancer has a poor prognosis because of high tumor metastasis and limited the...

    Jun Lu, Guangliang Li, Kuifeng He, Weiqin Jiang… in Journal of Translational Medicine (2015)

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  4. No Access

    Article

    FP3: a novel VEGF blocker with antiangiogenic effects in vitro and antitumour effects in vivo

    Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and neovascularisation in tumours. VEGF serves as a logical target for antiangiogenic cancer...

    Ketao **, Kuifeng He, Fei Teng, Guangliang Li… in Clinical and Translational Oncology (2011)

  5. No Access

    Article

    Gallbladder carcinoma incidentally encountered during laparoscopic cholecystectomy: how to deal with it

    Gallbladder cancer (GBC), characterised by rapid progression and a poor prognosis with a high mortality rate, is a complex disease to treat. Incidental gallbladder carcinoma (IGBC) is defined as carcinoma of t...

    Ketao **, Huanrong Lan, Tieming Zhu, Kuifeng He… in Clinical and Translational Oncology (2011)

  6. No Access

    Article

    Aflibercept (VEGF Trap): one more double-edged sword of anti-VEGF therapy for cancer?

    The use of vascular endothelial growth factor (VEGF)-targeted agents for treating cancer has increased dramatically over recent decades. These drugs provide considerable benefits in terms of progression-free (...

    Ketao **, Yan** Shen, Kuifeng He, Zhenzhen Xu… in Clinical and Translational Oncology (2010)

  7. No Access

    Article

    Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review

    Mouse cancer models have consistently been used to qualify new anticancer drugs in the development of human clinical trials. Rodent tumour models currently being used and which include transgenic tumour models...

    Ketao **, Lisong Teng, Yan** Shen, Kuifeng He… in Clinical and Translational Oncology (2010)