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Article

Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms t...

Christian Marx, Jürgen Sonnemann, Oliver D. K. Maddocks… in Cancer & Metabolism (2022)