18 Result(s)

Article

A brain-specific angiogenic mechanism enabled by tip cell specialization

Vertebrate organs require locally adapted blood vessels^1,2. The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing ...

Giel Schevenels, Pauline Cabochette, Michelle America, Arnaud Vandenborne… in Nature (2024)

Article

Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches

Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski… in Nature (2022)

Article

ADAMTS18⁺ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial...

Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone… in Nature Communications (2022)

Article

Digital immunoassay for biomarker concentration quantification using solid-state nanopores

Single-molecule counting is the most accurate and precise method for determining the concentration of a biomarker in solution and is leading to the emergence of digital diagnostic platforms enabling precision ...

Liqun He, Daniel R. Tessier, Kyle Briggs, Matthaios Tsangaris… in Nature Communications (2021)

Article

-308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and metabolic syndrome susceptibility: a meta-analysis

Many studies tried to assess the relationship between -308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and risk of metabolic syndrome (MS), but their results were contradictory. This meta-analysis...

Dong Wang, Liqun He, **aotian Zhang in Scientific Reports (2021)

Article

Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Lars Muhl, Guillem Genové, Stefanos Leptidis, Jian** Liu… in Nature Communications (2020)

Article

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

Many important cell types in adult vertebrates have a mesenchymal origin, including fibroblasts and vascular mural cells. Although their biological importance is undisputed, the level of mesenchymal cell heter...

Lars Muhl, Guillem Genové, Stefanos Leptidis, Jian** Liu… in Nature Communications (2020)

Article

Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model

Renal interstitial fibrosis (RIF) is currently recognized as a crucial mechanism of the pathogenesis of chronic kidney disease (CKD). Kangxianling (KXL, anti-fibrin) is a traditional Chinese medicine that has ...

Yufeng Jiang, Yaohan Zhu, Timing Zhen, Jie Li, Kaichen **ng, Liqun He… in Scientific Reports (2020)

Article

Reversible manipulation of the magnetic state in SrRuO₃ through electric-field controlled proton evolution

Ionic substitution forms an essential pathway to manipulate the structural phase, carrier density and crystalline symmetry of materials via ion-electron-lattice coupling, leading to a rich spectrum of electron...

Zhuolu Li, Shengchun Shen, Zijun Tian, Kyle Hwangbo, Meng Wang… in Nature Communications (2020)

Article

Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Mariana Castro Dias, Caroline Coisne, Ivana Lazarevic, Pascale Baden… in Scientific Reports (2019)

Article

Claudin-3-deficient C57BL/6J mice display intact brain barriers

The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/β-catenin signaling pathway regulating blood-brain barrier (BBB) maturation. In neurological disorders loss of cl...

Mariana Castro Dias, Caroline Coisne, Ivana Lazarevic, Pascale Baden… in Scientific Reports (2019)

Article

Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier

Diabetes mellitus is associated with cognitive impairment and various central nervous system pathologies such as stroke, vascular dementia, or Alzheimer’s disease. The exact pathophysiology of these conditions...

Maarja Andaloussi Mäe, Tian Li, Giacomo Bertuzzi… in Scientific Reports (2018)

Article

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

Vascular diseases are major causes of death, yet our understanding of the cellular constituents of blood vessels, including how differences in their gene expression profiles create diversity in vascular struct...

Liqun He, Michael Vanlandewijck, Maarja Andaloussi Mäe, Johanna Andrae… in Scientific Data (2018)

Article

Author Correction: A molecular atlas of cell types and zonation in the brain vasculature

In Fig. 1b of this Article, ‘Csf1r’ was misspelt ‘Csfr1’. In addition, in Extended Data Fig. 11b, owing to an error during figure formatting, the genes listed in the first column shifted down three rows below the...

Michael Vanlandewijck, Liqun He, Maarja Andaloussi Mäe, Johanna Andrae, Koji Ando… in Nature (2018)

Article

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known. He...

Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral… in Nature Communications (2018)

Article

Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema

Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. Paladin has also been proposed to be involved in various biological processes such as insu...

Isabel Egaña, Hiroshi Kaito, Anja Nitzsche, Lore Becker… in Scientific Reports (2017)

Article

Analysis of the brain mural cell transcriptome

Pericytes, the mural cells of blood microvessels, regulate microvascular development and function and have been implicated in many brain diseases. However, due to a paucity of defining markers, pericyte identi...

Liqun He, Michael Vanlandewijck, Elisabeth Raschperger… in Scientific Reports (2016)

Article

CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension

Inflammation plays an important role in the pathogenesis of hypertensive kidney disease. However, the molecular mechanisms underlying the induction of inflammation are not completely understood. We have found ...

Hua Liang, Zhiheng Ma, Hui Peng, Liqun He, Zhaoyong Hu, Yanlin Wang in Scientific Reports (2016)