11 Result(s)
within
Lihong Shi
Life Sciences
English
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Article
Pharmacological inhibition of EZH2 using a covalent inhibitor suppresses human ovarian cancer cell migration and invasion
Metastasis is the cause of poor prognosis in ovarian cancer (OC). Enhancer of Zeste homolog 2 (EZH2), a histone-lysine N-methyltransferase enzyme, promotes OC cell migration and invasion by regulating the express...
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Open AccessDecoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq
Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, whic...
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Article
Open AccessCancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7
Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is part...
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Article
Open AccessLinc00426 accelerates lung adenocarcinoma progression by regulating miR-455-5p as a molecular sponge
Increasing lines of evidence indicate the role of long non-coding RNAs (LncRNAs) in gene regulation and tumor development. Hence, it is important to elucidate the mechanisms of LncRNAs underlying the prolifera...
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Article
Open AccessCorrection to: MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1
An amendment to this paper has been published and can be accessed via the original article.
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Open AccessCorrection to: MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessMSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells
Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-...
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Open AccessR-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling
Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) ...
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Article
Open AccessMEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1
Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells fr...
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Open AccessGenome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes
The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 ...
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Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres
To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studi...
