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Article
Open AccessErythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia
Inherited non-hemolytic anemia is a group of rare bone marrow disorders characterized by erythroid defects. Although concerted efforts have been made to explore the underlying pathogenetic mechanisms of these ...
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Article
The heterogeneity of erythroid cells: insight at the single-cell transcriptome level
Erythroid cells, the most prevalent cell type in blood, are one of the earliest products and permeate through the entire process of hematopoietic development in the human body, the oxygen-transporting function...
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Article
Pharmacological inhibition of EZH2 using a covalent inhibitor suppresses human ovarian cancer cell migration and invasion
Metastasis is the cause of poor prognosis in ovarian cancer (OC). Enhancer of Zeste homolog 2 (EZH2), a histone-lysine N-methyltransferase enzyme, promotes OC cell migration and invasion by regulating the express...
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Chapter and Conference Paper
Research on the Application of BP Neural Network Algorithm in the Practical Teaching of Public Physical Education in Colleges and Universities
This article studies the application of BP neural network algorithm in practical teaching of public physical education in universities. Through the introduction and exploration of BP neural network algorithm, ...
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Article
Expression and Clinical Significance of HIF-1α in Follicular Fluid and Granulosa Cells in Infertile PCOS Patients
The present study aimed to determine the clinical predictive significance of HIF-1α in follicular development and assisted reproductive technology (ART). We collected follicular fluid (FF) and granulosa cells ...
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Article
Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis
Nonimmune cells can have immunomodulatory roles that contribute to healthy development. However, the molecular and cellular mechanisms underlying the immunomodulatory functions of erythroid cells during human ...
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Article
Open AccessDecoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq
Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, whic...
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Article
Open AccessImpacts of short-term tillage and crop residue incorporation managements on soil microbial community in a double-crop** rice field
Soil microbial community were usually reconsidered as a sensitive indicator in soil quality and soil environment change of paddy field. However, the effects of different tillage and crop residue incorporation ...
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Article
Open AccessCancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7
Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is part...
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Article
β-cyclodextrin modified xanthan gum as an eco-friendly corrosion inhibitor for L80 steel in 1 M HCl
The development of eco-friendly corrosion inhibitors is a subject of several investigations, especially natural polymers. Aimed at suppressing the corrosion of L80 steel in 1 mol/L hydrochloric acid (HCl), a n...
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Article
Open AccessEffects of fertilizer practice on fungal and actinobacterial cellulolytic community with different humified particle-size fractions in double-crop** field
Cellulose plays an important role in maintaining or improving soil carbon (C) cycling and soil fertility of paddy field. There had close relationship between functional cellulose genes (cbhI and GH48) with charac...
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Article
Functional soil organic matter fraction in response to short-term tillage management under the double-crop** rice paddy field in southern of China
Soil organic matter (SOM) and its fraction play an important role in maintaining and improving soil fertility of paddy field. However, there is still limited information about how SOM fraction response to carb...
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Article
Open AccessSingle-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
Human FOXP3+ regulatory T (Treg) cells are central to immune tolerance. However, their heterogeneity and differentiation remain incompletely understood. Here we use single-cell RNA and T cell receptor sequencing ...
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Article
Distinct temporal evolution of PILS distribution in congruent and near-stoichiometric LiNbO3:Fe crystals detected by in-situ dynamic angular spectra
In this paper, congruent and near-stoichiometric LiNbO3:Fe (CLN:Fe and SLN:Fe) crystals are prepared through Czochralski and Vapour-transport-equilibration techniques, and the temporal evolution of the photoinduc...
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Article
Open AccessMicrobial carbon source utilization in rice rhizosphere soil with different tillage practice in a double crop** rice field
Carbon (C) plays an important role in maintaining soil fertility and increasing soil microbial community, but there is still limited information about how source utilization characteristics respond to soil fer...
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Article
Application of Graphene in Coating Silk Fibril for Tunable Infrared Absorption
Infrared radiation is a primary mechanism for heat exchange between the human body and the environment. In the framework of Mie scattering theory, we investigate the infrared absorption of a graphene-coated si...
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Article
Open AccessCD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance
Cancer stem-like cells (CSCs) are associated with cancer progression, metastasis, and recurrence, and may also represent a subset of circulating tumor cells (CTCs). In our prior study, CTCs in advanced prostat...
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Article
Open AccessThe effectiveness and safety of Tai Chi for patients with essential hypertension: study protocol for an open-label single-center randomized controlled trial
Evidence showed that Tai Chi may have beneficial effects among hypertensive individuals, although the results are not convincing. We aim to conduct a high-quality clinical trial with 24-h BP measurement to pro...
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Article
Open AccessLinc00426 accelerates lung adenocarcinoma progression by regulating miR-455-5p as a molecular sponge
Increasing lines of evidence indicate the role of long non-coding RNAs (LncRNAs) in gene regulation and tumor development. Hence, it is important to elucidate the mechanisms of LncRNAs underlying the prolifera...
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Article
Competitive Adsorption and Mobility of Propiconazole and Difenoconazole on Five Different Soils
Propiconazole (PPC) and difenoconazole (DFC) are often combined for field applications. The resulted co-exsistence of PPC and DFC may have an effect on the fate of their individuals in soil. In this study, ads...
