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  1. Article

    Open Access

    Epigenetic and transcriptional determinants of the human breast

    While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-n...

    Philippe Gascard, Misha Bilenky, Mahvash Sigaroudinia… in Nature Communications (2015)

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    Protocol

    Using ChIP-Seq Technology to Generate High-Resolution Profiles of Histone Modifications

    The dynamic modification of DNA and histones plays a key role in transcriptional regulation through ­altering the packaging of DNA and modifying the nucleosome surface. These chromatin states, also referred to...

    Henriette O’Geen, Lorigail Echipare, Peggy J. Farnham in Epigenetics Protocols (2011)

  3. Article

    Open Access

    Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes

    The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 ...

    Henriette O'Geen, Yu-Hsuan Lin, **aoqin Xu, Lorigail Echipare… in BMC Genomics (2010)

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    Article

    Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

    Methods for profiling DNA methylation differ in the physical principles used to detect modified cytosines. Harris et al. compare the performances of four sequencing-based technologies for genome-wide analysis of ...

    R Alan Harris, Ting Wang, Cristian Coarfa, Raman P Nagarajan… in Nature Biotechnology (2010)