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Article
Open AccessClustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort
Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grou** patients into hypoinflammato...
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Article
Open AccessEuropean Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI
Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to the intensive care unit (ICU). We aim to report the clinical characteristics of ICU-admitted pati...
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Article
Correction: ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
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ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
Severe community-acquired pneumonia (sCAP) is associated with high morbidity and mortality, and whilst European and non-European guidelines are available for community-acquired pneumonia, there are no specific...
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Article
Defining basic (lung) ultrasound skills: not so basic after all?
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Article
Open AccessDead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS.
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Article
Open AccessPrognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia—insights from the MARS study
Outcome prediction in patients with acute respiratory distress syndrome (ARDS) greatly improves when patients are reclassified based on predefined arterial oxygen partial pressure to fractional inspired oxygen...
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Article
Open AccessThe effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients
Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures. The complement system has been suggested to play a causative...
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Article
Open AccessThe predictive validity for mortality of the driving pressure and the mechanical power of ventilation
Outcome prediction in critically ill patients under invasive ventilation remains extremely challenging. The driving pressure (ΔP) and the mechanical power of ventilation (MP) are associated with patient-center...
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Article
Open AccessThe importance of airway and lung microbiome in the critically ill
During critical illness, there are a multitude of forces such as antibiotic use, mechanical ventilation, diet changes and inflammatory responses that could bring the microbiome out of balance. This so-called d...
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Article
Open AccessAcute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis
Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of A...
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Article
Open AccessEstimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS
Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. Thi...
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Article
Open AccessWhy translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III)
Current treatment of acute respiratory distress syndrome (ARDS) in critically ill patients is limited to supportive measures including mechanical ventilation. It is our view that effective therapies for ARDS c...
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Open AccessThe role of hypercapnia in acute respiratory failure
The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times contradictory. On the one hand, it may have protective...
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Article
Open AccessManipulation of the microbiome in critical illness—probiotics as a preventive measure against ventilator-associated pneumonia
To describe the possible modes of action of probiotics and provide a systematic review of the current evidence on the efficacy of probiotics to prevent ventilator-associated pneumonia (VAP) in critically ill p...
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Open AccessAge-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study
Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respir...
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Article
Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts
Mechanical power (MP) may unify variables known to be related to development of ventilator-induced lung injury. The aim of this study is to examine the association between MP and mortality in critically ill pa...
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Article
Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study
To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification.
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Article
Open AccessRisk stratification using SpO2/FiO2 and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS
We assessed the potential of risk stratification of ARDS patients using SpO2/FiO2 and positive end-expiratory pressure (PEEP) at ARDS onset and after 24 h.
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Article
Selective decontamination of the digestive tract halves the prevalence of ventilator-associated pneumonia compared to selective oral decontamination
