-
Article
CDKN2A somatic copy number amplification in normal tissues surrounding gastric carcinoma reduces cancer metastasis risk in droplet digital PCR analysis
The CDKN2A gene is frequently affected by somatic copy number variations (SCNVs, including deletions and amplifications [SCNdel and SCNamp]) in the cancer genome. Using surgical gastric margin tissue samples (SMs...
-
Article
Open AccessDUSP5P1 promotes gastric cancer metastasis and platinum drug resistance
We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseudogene 1) in gastric carcinogenesis. We demonstrated that gastric cancer (GC) patients w...
-
Article
Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy
We identified gamma-glutamyltransferase 7 (GGT7) to be frequently downregulated in gastric cancer, but its role remains unknown. Here we elucidated the clinical significance, functional roles, and molecular mecha...
-
Article
Open AccessThe clinical value and usage of inflammatory and nutritional markers in survival prediction for gastric cancer patients with neoadjuvant chemotherapy and D2 lymphadenectomy
The clinical values of inflammatory and nutritional markers remained unclear for gastric cancer with neoadjuvant chemotherapy (NACT).
-
Article
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity
Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfunction is therefore central to cancer immunotherapy. Here, we report that du...
-
Chapter and Conference Paper
Experimental Study on Pore Water Pressure and Microstructures of Silty Clay Under Freeze-Thaw Cycles
The variations on physical properties and microstructures of soils are essential to explore the freeze-thaw mechanisms. We do some experiments on freeze-thaw test of Qinghai-Tibet silty clay and cryo-scanning ...
-
Article
Open AccessA panel of DNA methylated markers predicts metastasis of pN0M0 gastric carcinoma: a prospective cohort study
The aim of this prospective study was to evaluate the feasibility of predicting GC metastasis using CDH1, GFRA1, P16 and ZNF382 DNA methylation as biomarkers.
-
Article
Open AccessImpact of postoperative major complications on long-term survival after radical resection of gastric cancer
This study was designed to evaluate the impact of postoperative major complications on long-term survival following curative gastrectomy.
-
Article
Open AccessDifferent prognostic implication of ypTNM stage and pTNM stage for gastric cancer: a propensity score-matched analysis
Pathological stage is considered as the best prognosis indicator for gastric cancer. With the increasing use of neoadjuvant chemotherapy (NACT), the latest TNM staging included a new pathological stage of ypTN...
-
Article
Open AccessAuthor Correction: A proteomic landscape of diffuse-type gastric cancer
The original version of this Article contained an error in the email address of the corresponding author Jun Qin. The correct email is jqin1965@126.com. The error has been corrected in the HTML and PDF version...
-
Article
Open AccessA proteomic landscape of diffuse-type gastric cancer
The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of 11,340 gene pr...
-
Article
Open AccessStaging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study
Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regul...
-
Article
Open AccessPrognostic value of a 25-gene assay in patients with gastric cancer after curative resection
This study aimed to develop and validate a practical, reliable assay for prognosis and chemotherapy benefit prediction compared with conventional staging in Gastric cancer (GC). Twenty-three candidate genes wi...
-
Article
Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy: safety and short-term oncologic results
To compare the safety and efficacy of laparoscopic distal gastrectomy (LDG) versus open distal gastrectomy (ODG) in treating locally advanced distal gastric cancer after neoadjuvant chemotherapy (NACT).
-
Article
Open AccessA nomogram for predicting the likelihood of lymph node metastasis in early gastric patients
Early gastric cancer is defined as a lesion confined to the mucosa or submucosa, regardless of the size or lymph node metastasis. Treatment methods include endoscopic mucosal resection or endoscopic submucosal...
-
Article
Open AccessGastrectomy in comprehensive treatment of advanced gastric cancer with synchronous liver metastasis: a prospectively comparative study
Systemic chemotherapy is the key treatment for advanced gastric cancer. The benefit of adjuvant surgery following preoperative chemotherapy in gastric cancer with liver metastasis has not been well established.
-
Article
Open AccessOncogenic HER2 fusions in gastric cancer
Genetic amplification of HER2 drives tumorigenesis and cancer progression in a subset of patients with gastric cancer (GC), and treatment with trastuzumab, a humanized HER2-neutralizing antibody, improves the ove...
-
Article
Open AccessThe extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice
Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying human tumor biology. However, the occasional occurrence of lymphomagenesis in some mice can spoil the model...
-
Article
Open AccessCSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest
Cytokines are soluble proteins that exert their functions by binding specific receptors. Many cytokines play essential roles in carcinogenesis and have been developed for the treatment of cancer. In this study...
-
Article
Open AccessErratum to: Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma
