-
Article
Multikingdom and functional gut microbiota markers for autism spectrum disorder
Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial component of the microbiome. Whether gut archaea, fungi and...
-
Article
Open AccessCOVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition
Newborns can acquire immunological protection to SARS-CoV-2 through vaccine-conferred antibodies in human breast milk. However, there are some concerns around lactating mothers with regards to potential short-...
-
Article
Open AccessBaseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines
The role of gut microbiota in modulating the durability of COVID-19 vaccine immunity is yet to be characterised. In this cohort study, we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vacc...
-
Article
Open AccessGut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior d...
-
Article
Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications
The gastrointestinal tract is involved in coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gut microbiota has important roles in viral entry recep...
-
Article
Open AccessFaecal microbiome-based machine learning for multi-class disease diagnosis
Systemic characterisation of the human faecal microbiome provides the opportunity to develop non-invasive approaches in the diagnosis of a major human disease. However, shared microbial signatures across diffe...
-
Article
Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy
We identified gamma-glutamyltransferase 7 (GGT7) to be frequently downregulated in gastric cancer, but its role remains unknown. Here we elucidated the clinical significance, functional roles, and molecular mecha...
-
Article
Open AccessPrevotella species in the human gut is primarily comprised of Prevotella copri, Prevotella stercorea and related lineages
Prevotella species in the human gut microbiome are primarily comprised of Prevotella copri, and its diversity and function were recently investigated in detail. Much less is known about other Prevotella species i...
-
Article
Open AccessGut microbiota in patients with obesity and metabolic disorders — a systematic review
Previous observational studies have demonstrated inconsistent and inconclusive results of changes in the intestinal microbiota in patients with obesity and metabolic disorders. We performed a systematic review...
-
Article
Modulation of gut microbiota protects against viral respiratory tract infections: a systematic review of animal and clinical studies
Earlier studies suggest that probiotics have protective effects in the prevention of respiratory tract infections (RTIs). Whether such benefits apply to RTIs of viral origin and mechanisms supporting the effec...
-
Article
Open AccessTemporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity
Coronavirus disease 2019 (COVID-19) caused by the enveloped RNA virus SARS-CoV-2 primarily affects the respiratory and gastrointestinal tracts. SARS-CoV-2 was isolated from fecal samples, and active viral repl...
-
Article
Open AccessLongitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease
Fecal microbiota transplant (FMT) has emerged as a potential treatment for severe colitis associated with graft-versus-host disease (GvHD) following hematopoietic stem cell transplant. Bacterial engraftment fr...
-
Article
Open AccessCurrent knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review
Recent advances in small-bowel endoscopy such as capsule endoscopy have shown that non-steroidal anti-inflammatory drugs (NSAIDs) frequently damage the small intestine, with the prevalence rate of mucosal brea...
-
Article
Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity
Emerging evidence implicates a role of the gut microbiota in colorectal cancer (CRC). Peptostreptococcus anaerobius (P. anaerobius) is an anaerobic bacterium selectively enriched in the faecal and mucosal microbi...
-
Article
Open AccessDiversity of macaque microbiota compared to the human counterparts
Studies on the microbial communities in non-human primate hosts provide unique insights in both evolution and function of microbes related to human health and diseases. Using 16S rRNA gene amplicon profiling, ...
-
Article
Open AccessGut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection
Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile infection (CDI). Bacterial colonization in recipients after FMT has been studied, but little is known about the role...
-
Article
Open AccessMulti-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers
Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes...
-
Article
Open AccessGlobal Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries
Oesophageal cancers (adenocarcinomas [AC] and squamous cell carcinomas [SCC]) are characterized by high incidence/mortality in many countries. We aimed to delineate its global incidence and mortality, and stud...
-
Article
Open AccessComparative effectiveness research: what to do when experts disagree about risks
Ethical issues related to comparative effectiveness research, or research that compares existing standards of care, have recently received considerable attention. In this paper we focus on how Ethics Review Commi...
-
Article
Open AccessValidation of a risk prediction score for proximal neoplasia in colorectal cancer screening: a prospective colonoscopy study
This study developed a clinical scoring system to predict the risks of PN among screening participants for colorectal cancer. We recruited 5,789 Chinese asymptomatic screening participants who received colonos...
