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Open Accessp38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons
We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of dorsal root ganglia (DRGs) stimulate ATP release. The ATP activates P2Y1Rs located in the enwrap...
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Open AccessAnalgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery
Phosphorylation sites in the C-terminus of mu-opioid receptors (MORs) are known to play critical roles in the receptor functions. Our understanding of their participation in opioid analgesia is mostly based on...
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Article
Open AccessP2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons
The purinergic P2X3 receptor (P2X3R) expressed in the dorsal root ganglion (DRG) sensory neuron and the P2X7 receptor (P2X7R) expressed in the surrounding satellite glial cell (SGC) are two major receptors par...
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Open AccessMechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats
Diabetic neuropathy is a common neuropathy associated with paresthaesia and pain. The mechanisms underlying the painful conditions are not well understood. The aim of this study is to investigate the participa...
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Article
Open AccessProstaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons
Prostaglandin E2 (PGE2) is a well-known inflammatory mediator that enhances the excitability of DRG neurons. Homomeric P2X3 and heteromeric P2X2/3 receptors are abundantly expressed in dorsal root ganglia (DRG...
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Article
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation
THE roles of N-methyl-D-aspartate (NMDA) receptors and protein kinase C (PKC) are critical in generating and maintaining a variety of sustained neuronal responses. In the nociceptive (pain-sensing) system, tissue...
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Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons
GLYCINE is an important inhibitory transmitter in the brainstem and spinal cord1,2. In the trigeminal subnucleus caudalis (medullary dorsal horn) and in the spinal dorsal horn (the relaying centres for processing...
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What We Have Learned from Patch Recordings of Cultured Cells
Dissociated neural cell cultures have been used as model systems to study a host of questions in neurobiology such as regulation of cell differentiation, interactions between cells, mechanisms of morphogenesis...
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Dynamic properties of polyelectrolyte calcium membranes
Shashoua observed spontaneous oscillations in a polyelectrolyte membrane formed by interfacial precipitates of polyacid and polybase. We have here undertaken experimental and theoretical studies of polyglutami...
