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  1. No Access

    Article

    Adherence to osteoporosis guideline: survey among Czech general practitioners

    General practitioners (GPs) play an important role in management of patients at risk of osteoporosis (OP). The objectives were to assess (1) knowledge about OP and use of OP clinical guideline in comparison wi...

    Magda Vytrisalova, Leos Fuksa, Vladimir Palicka… in Central European Journal of Medicine (2014)

  2. No Access

    Article

    Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase

    Methotrexate (MTX) released from bone cement showed a useful local effect in animal models of bone tumours. However, local toxic reactions such as impaired wound healing were observed in areas surrounding the ...

    Egon Prochazka, Tomas Soukup, Milos Hroch, Leos Fuksa… in International Orthopaedics (2010)

  3. No Access

    Article

    Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes and organ involvement in systemic sclerosis

    Oxidative stress is suggested to be involved in the pathogenesis of systemic sclerosis (SSc). The aim of the present study was to clarify such a hypothesis by determination of four different plasmatic paramete...

    Valeria Riccieri, Antonio Spadaro, Leos Fuksa, Omidreza Firuzi… in Clinical Rheumatology (2008)

  4. No Access

    Article

    Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions

    Objective: The aim of the present study was to predict the drug interaction potential of memantine by elucidation of its inhibitory effects on cytochrome P450 enzymes using pooled human liver microsomes (HLM) and...

    Stanislav Micuda, Lucie Mundlova… in European Journal of Clinical Pharmacology (2004)