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  1. No Access

    Article

    TAK1 signaling is a potential therapeutic target for pathological angiogenesis

    Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can promote neoplastic diseases and retinopathies, while inadequate angiogenesis can lead to ...

    Linxin Zhu, Suraj Lama, Leilei Tu, Gregory J. Dusting, Jiang-Hui Wang… in Angiogenesis (2021)

  2. No Access

    Article

    A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization

    Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal vascular leakage and neovascularization. However, constitutive suppression of VE...

    **ying Chen, Fan-Li Lin, Jacqueline Y. K. Leung, Leilei Tu, Jiang-Hui Wang… in Angiogenesis (2021)

  3. No Access

    Article

    AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

    Ocular neovascularization is a common pathological feature in diabetic retinopathy and neovascular age-related macular degeneration that can lead to severe vision loss. We evaluated the therapeutic efficacy of...

    Leilei Tu, Jiang-Hui Wang, Veluchamy A. Barathi, Selwyn M. Prea, Zheng He… in Angiogenesis (2018)