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  1. No Access

    Article

    TAK1 signaling is a potential therapeutic target for pathological angiogenesis

    Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can promote neoplastic diseases and retinopathies, while inadequate angiogenesis can lead to ...

    Linxin Zhu, Suraj Lama, Leilei Tu, Gregory J. Dusting, Jiang-Hui Wang… in Angiogenesis (2021)

  2. No Access

    Article

    A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization

    Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal vascular leakage and neovascularization. However, constitutive suppression of VE...

    **ying Chen, Fan-Li Lin, Jacqueline Y. K. Leung, Leilei Tu, Jiang-Hui Wang… in Angiogenesis (2021)

  3. No Access

    Article

    Emerging Technologies to Solve the Key Issues in Endothelial Keratoplasty

    Endothelial keratoplasty (EK) is increasingly used to treat corneal endothelial disease. However, issues remain with EK including a non-zero rejection rate, shortage of donor tissue, and technical challenges f...

    Karl David Brown, Gregory J. Dusting, Mark Daniell in Current Ophthalmology Reports (2020)

  4. No Access

    Article

    AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

    Ocular neovascularization is a common pathological feature in diabetic retinopathy and neovascular age-related macular degeneration that can lead to severe vision loss. We evaluated the therapeutic efficacy of...

    Leilei Tu, Jiang-Hui Wang, Veluchamy A. Barathi, Selwyn M. Prea, Zheng He… in Angiogenesis (2018)

  5. Article

    Open Access

    Biologically active constituents of the secretome of human W8B2+ cardiac stem cells

    The benefits of adult stem cells for repair of the heart have been attributed to the repertoire of salutary paracrine activities they appear to exert. We previously isolated human W8B2+ cardiac stem cells (CSCs) ...

    Shuai Nie, **n Wang, Priyadharshini Sivakumaran, Mark M. W. Chong… in Scientific Reports (2018)

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    Protocol

    Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A

    Human induced pluripotent stem (iPS) cells are a promising source of autologous cardiomyocytes to repair and regenerate myocardium for treatment of heart disease. In this study, we describe a method for enhanc...

    Shiang Y. Lim Ph.D., Priyadharshini Sivakumaran… in Induced Pluripotent Stem (iPS) Cells (2016)

  7. Article

    Open Access

    Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke

    Despite attempts to prevent brain injury during the hyperacute phase of stroke, most sufferers end up with significant neuronal loss and functional deficits. The use of cell-based therapies to recover the inju...

    Hima C. S. Abeysinghe, Laita Bokhari, Anita Quigley… in Stem Cell Research & Therapy (2015)

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  8. No Access

    Article

    Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells

    Reactive oxygen species (ROS) such as superoxide and hydrogen peroxide (H2O2) have been implicated in development and progression of breast cancer. In the present study, we have evaluated the effects of the super...

    Manisha H. Shah, Guei-Sheung Liu, Erik W. Thompson… in Breast Cancer Research and Treatment (2015)

  9. No Access

    Article

    Smad-independent pathway involved in transforming growth factor β1-induced Nox4 expression and proliferation of endothelial cells

    NADPH oxidase-derived reactive oxygen species are important for various cellular functions, including proliferation. Endothelial cells predominantly express the Nox4 isoform of NADPH oxidase, but it is not ent...

    Nora Y. Hakami, Henry Wong, Manisha H. Shah… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2015)

  10. No Access

    Article

    Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes

    Activators of protease-activated receptors PAR-1 and PAR-2 such as thrombin and synthetic hexapeptides promote hypertrophy of isolated neonatal cardiomyocytes at pathological concentrations. Since PAR-activati...

    Anke C. Fender, Goran Pavic… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2014)

  11. No Access

    Reference Work Entry In depth

    NADPH Oxidase in Tissue Repair and Regeneration

    Redox homeostasis is a delicate balance maintaining physiological signaling functions of free radicals as well as antioxidant capacity to prevent excess free radical overflow. Disturbance of this redox equilib...

    Elsa C. Chan, G S. Liu, Carli L. Roulston… in Systems Biology of Free Radicals and Antio… (2014)

  12. No Access

    Article

    NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival

    Proliferation and apoptosis of endothelial cells are crucial angiogenic processes that contribute to carcinogenesis and tumor progression. Emerging evidence implicates the regulation of proliferation and apopt...

    Hitesh Peshavariya, Gregory J. Dusting… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2009)

  13. No Access

    Article

    Inhibition of vascular smooth muscle relaxation by LY83583

    The ability of LY83583 to antagonize vascular smooth muscle relaxation elicited by a number of vasodilators was examined in rings of rat aorta. LY83583 (0.3–10 μM) inhibited relaxant responses to acetylcholine...

    Errol Malta, Peter S. Macdonald… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1988)