14 Result(s)

Article

Correction: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun… in Molecular Psychiatry (2024)

Article

Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia

Childhood trauma (CT) is associated with lower cognitive and social cognitive function in schizophrenia. Recent evidence suggests that the relationship between CT and cognition is mediated by both low-grade sy...

Sinead King, David Mothersill, Laurena Holleran… in Translational Psychiatry (2023)

Article

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ ...

Constantinos Constantinides, Laura K. M. Han, Clara Alloza… in Molecular Psychiatry (2023)

Article

Correction: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun… in Molecular Psychiatry (2022)

Article

Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia....

Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun… in Molecular Psychiatry (2022)

Article

Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls

Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-...

Emma Corley, Laurena Holleran, Laura Fahey, Aiden Corvin… in Translational Psychiatry (2021)

Article

Correction to: Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment

Giulia Tronchin, Theophilus N. Akudjedu, Mohamed Ahmed… in Neuropsychopharmacology (2021)

Article

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Hu...

Ida E. Sønderby, Dennis van der Meer, Clara Moreau… in Translational Psychiatry (2021)

Article

White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals

Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group perfo...

Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Kentaro Morita… in Molecular Psychiatry (2020)

Article

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human b...

Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching… in Translational Psychiatry (2020)

Article

Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in...

Ida E. Sønderby, Ómar Gústafsson, Nhat Trung Doan, Derrek P. Hibar… in Molecular Psychiatry (2020)

Article

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Carriers of large recurrent copy number variants (CNVs) have a higher risk of develo** neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizoph...

Ida E Sønderby, Ómar Gústafsson, Nhat Trung Doan, Derrek P Hibar… in Molecular Psychiatry (2020)

Article

Progressive Brain Atrophy and Cortical Thinning in Schizophrenia after Commencing Clozapine Treatment

Despite evidence that clozapine may be neuroprotective, there are few longitudinal magnetic resonance imaging (MRI) studies that have specifically explored an association between commencement of clozapine trea...

Mohamed Ahmed, Dara M Cannon, Cathy Scanlon, Laurena Holleran… in Neuropsychopharmacology (2015)

Article

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left ...

Laurena Holleran, Mohamed Ahmed, Heike Anderson-Schmidt… in Neuropsychopharmacology (2014)