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Article
Open AccessProbabilistic inference of the genetic architecture underlying functional enrichment of complex traits
We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 m...
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Article
Open AccessInvestigating Stochastic Differential Equations Modelling for Levodopa Infusion in Patients with Parkinson’s Disease
Levodopa concentration in patients with Parkinson’s disease is frequently modelled with ordinary differential equations (ODEs). Here, we investigate a pharmacokinetic model of plasma levodopa concentration in ...
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Genomic Selection
Prediction of phenotypes is not only used for selection and breeding in animal and plant populations but also for the assessment of specific phenotypes, especially predisposition to diseases and disorders in h...
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Article
Open AccessModelling the co-evolution of indirect genetic effects and inherited variability
When individuals interact, their phenotypes may be affected not only by their own genes but also by genes in their social partners. This phenomenon is known as Indirect Genetic Effects (IGEs). In aquaculture s...
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Article
Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes)
Individuals involved in a social interaction exhibit different behavioral traits that, in combination, form the individual’s behavioral responses. Selectively bred strains of silver foxes (Vulpes vulpes) demonstr...
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Article
Open AccessWind farm construction impacts reindeer migration and movement corridors
Over the last decade, we have seen a massive increase in the construction of wind farms in northern Fennoscandia. Wind farms comprising hundreds of wind turbines are being built, with little knowledge of the p...
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Article
Open AccessGenetic heterogeneity of within-family variance of body weight in Atlantic salmon (Salmo salar)
Canalization is defined as the stability of a genotype against minor variations in both environment and genetics. Genetic variation in degree of canalization causes heterogeneity of within-family variance. The...
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Article
Open AccessEstimation of genetic variance for macro- and micro-environmental sensitivity using double hierarchical generalized linear models
Genetic variation for environmental sensitivity indicates that animals are genetically different in their response to environmental factors. Environmental factors are either identifiable (e.g. temperature) and...
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Article
Open AccessRecent developments in statistical methods for detecting genetic loci affecting phenotypic variability
A number of recent works have introduced statistical methods for detecting genetic loci that affect phenotypic variability, which we refer to as variability-controlling quantitative trait loci (vQTL). These ar...
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Estimation and Interpretation of Genetic Effects with Epistasis Using the NOIA Model
We introduce this communication with a brief outline of the historical landmarks in genetic modeling, especially concerning epistasis. Then, we present methods for the use of genetic modeling in QTL analyses. ...
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Article
Open AccessHierarchical likelihood opens a new way of estimating genetic values using genome-wide dense marker maps
Genome-wide dense markers have been used to detect genes and estimate relative genetic values. Among many methods, Bayesian techniques have been widely used and shown to be powerful in genome-wide breeding val...
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Article
Open AccessFine map** and replication of QTL in outbred chicken advanced intercross lines
Linkage map** is used to identify genomic regions affecting the expression of complex traits. However, when experimental crosses such as F2 populations or backcrosses are used to map regions containing a Quanti...
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Article
Open AccessGenetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models
The sensitivity to microenvironmental changes varies among animals and may be under genetic control. It is essential to take this element into account when aiming at breeding robust farm animals. Here, linear ...
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Article
Open AccessModelling dominance in a flexible intercross analysis
The aim of this paper is to develop a flexible model for analysis of quantitative trait loci (QTL) in outbred line crosses, which includes both additive and dominance effects. Our flexible intercross analysis ...
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Article
Open AccessSeparation of base allele and sampling term effects gives new insights in variance component QTL analysis
Variance component (VC) models are commonly used for Quantitative Trait Loci (QTL) map** in outbred populations. Here, the QTL effect is given as a random effect and a critical part of the model is the relat...
