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Article
Open AccessRespiratory muscle dysfunction in long-COVID patients
Symptoms often persistent for more than 4 weeks after COVID-19—now commonly referred to as ‘Long COVID’. Independent of initial disease severity or pathological pulmonary functions tests, fatigue, exertional i...
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Article
Open AccessOrganbezogene Folgeerscheinungen von COVID‑19 bei Erwachsenen
Organbezogene Folgeerscheinungen nach COVID-19 sind häufig und vielgestaltig. Ab 4 Wochen nach Akutinfektion mit SARS-CoV‑2 werden sie unter dem Begriff „Long-COVID“ zusammengefasst.
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Article
Open AccessGenetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study
Observational studies on the general population have suggested that airflow obstruction associates with left ventricular (LV) filling. To limit the influence of environmental risk factors/exposures, we used a ...
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Article
The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension
Dysfunction of the pulmonary endothelium is associated with most lung diseases. Extracellular nucleotides modulate a plethora of endothelial functions in the lung such as vessel integrity, vasodilatation, infl...
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Article
Open AccessLymph node retrieval in colorectal cancer: determining factors and prognostic significance
The study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and to evaluate its prognostic impact in patients with colorectal cancer (CRC).
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Article
Open AccessExploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension
Chronic inflammation emerges as a feature of the pathogenesis of pulmonary arterial hypertension (PAH) in experimental models. Alterations of circulating cell subsets have been observed in patients with PAH. W...
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Article
Open AccessAcute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension
Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothe...
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Article
Open AccessMUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance
Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for MUC...
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Inclusion of cytological features in tumor grading improves prognostic stratification of patients with colorectal cancer
Tumor grade is a traditional prognostic parameter in colorectal cancer. Remarkably, however, there is still no generally accepted consensus how to perform tumor grading. In this study, we systematically compar...
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Article
Open AccessTumour budding with and without admixed inflammation: two different sides of the same coin?
Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cance...
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Article
Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension
Gremlin-1, an intrinsic antagonist of bone morphogenetic protein (BMP) signaling, has been implicated in the pathophysiology of pulmonary arterial hypertension (PAH). However, it is unknown whether gremlin-1 c...
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Article
Open AccessFibrinogen plasma concentration is an independent marker of haemodynamic impairment in chronic thromboembolic pulmonary hypertension
Fibrinogen has a crucial role in both inflammation and coagulation, two processes pivotal for the pathogenesis of pulmonary hypertension. We therefore aimed to investigate whether fibrinogen plasma concentrati...
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Article
Treatment with dasatinib for chronic myeloid leukemia following imatinib-induced hepatotoxicity
Treatment with the tyrosine kinase inhibitor (TKI) imatinib for chronic myeloid leukemia in chronic phase (CML-CP) of disease may cause severe hepatotoxicity in rare cases. However, it remains unclear (1) how ...
