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Using urine metabolomics to understand the pathogenesis of infant respiratory syncytial virus (RSV) infection and its role in childhood wheezing
Respiratory syncytial virus (RSV) infection in infants causes significant morbidity and is the strongest risk factor associated with asthma. Metabolites, which reflect the interactions between host cell and vi...
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Article
Open AccessRespiratory Syncytial Virus whole-genome sequencing identifies convergent evolution of sequence duplication in the C-terminus of the G gene
Respiratory Syncytial Virus (RSV) is responsible for considerable morbidity and mortality worldwide and is the most important respiratory viral pathogen in infants. Extensive sequence variability within and be...
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Article
Minimally Invasive Sampling Method Identifies Differences in Taxonomic Richness of Nasal Microbiomes in Young Infants Associated with Mode of Delivery
To date, there is a limited understanding of the role of the airway microbiome in the early life development of respiratory diseases such as asthma, partly due to a lack of simple and minimally invasive sample...
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Article
Open AccessObjectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE)
Respiratory syncytial virus (RSV) lower respiratory tract infection (LRI) during infancy has been consistently associated with an increased risk of childhood asthma. In addition, evidence supports that this re...
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Book
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Chapter
Challenges and Opportunities for Respiratory Syncytial Virus Vaccines
Respiratory syncytial virus (RSV) causes a significant proportion of the global burden of respiratory disease. Here we summarize the conclusions of a series of chapters written by investigators describing and ...
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Chapter
Clinical and Epidemiologic Features of Respiratory Syncytial Virus
Since its discovery in 1955, respiratory syncytial virus (RSV) has consistently been noted to be the single most important cause of lower respiratory tract illness in infants <1 year of age. RSV also causes re...
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Article
Refractory Status Epilepticus in Suspect Encephalitis
The California Encephalitis Project (CEP) is a program designed to determine causes of encephalitis. We sought to determine whether there are any distinguishing characteristics of patients with encephalitis wh...
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Article
CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein
Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell tr...
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Article
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition receptors for microbial products. Two important me...
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Article
Antigenic and Genetic Diversity among the Attachment Proteins of Group A Respiratory Syncytial Viruses which have caused Repeat Infections in Children† 917
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Chapter
Strains of Respiratory Syncytial Virus: Implications for Vaccine Development
Within a few years after its discovery in 1957, respiratory syncytial virus (RSV) was shown to be the single most important pathogen of acute lower respiratory tract illness among infants and young children wo...
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Chapter
Monoclonal Time-Resolved Fluoroimmunoassay: Sensitive Systems for the Rapid Diagnosis of Respiratory Virus Infections
The respiratory viruses afflict everyone, causing an average of three respiratory illnesses per person per year and millions of lost work days per year, at an enormous economic cost. There are over 200 viruses...
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Chapter
Paramyxoviridae: Respiratory Syncytial Virus
Disease: Acute upper and lower respiratory tract illness.
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Chapter
Nosocomial Viral Infections
Disease: Viral infections and their associated illnesses acquired in the hospital or other health care facility.
