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Article
Open AccessPhysiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS
Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these age-associated changes and their contribution to diseases are onl...
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Article
Open AccessThe astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution to CNS pathologies including multiple sclerosis ...
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Article
Open AccessmeQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes
Little is known about how genetics and epigenetics interplay in depression. Evidence suggests that genetic variants may change vulnerability to depression by modulating DNA methylation (DNAm) and non-coding RN...
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Article
Open AccessNeuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA m...
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DNA Methylation in Multiple Sclerosis
Multiple Sclerosis (MS) is a leading cause of lifelong disability in young adults. The disease strikes individuals in their most productive years with incurable and progressive course that results in developme...
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Article
Open AccessCompetitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Circulating monocytes can compete for virtually any tissue macrophage niche and become long-lived replacements that are phenotypically indistinguishable from their embryonic counterparts. As the factors regula...
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Article
Open AccessDNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers...
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Article
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
The cytokine transforming growth factor-β (TGF-β) regulates the development and homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β is not critical for microglia survival but...
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Article
Open AccessAuthor Correction: Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessUsability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies
The advent of array-based genome-wide DNA methylation methods has enabled quantitative measurement of single CpG methylation status at relatively low cost and sample input. Whereas the use of Infinium Human Me...
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Article
Open AccessSmoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a chronic inflammatory and neurodegenerative disease, although a mechanistic basis remains largely unknown. We aimed a...
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Article
Open AccessNOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9
Sustained neuroinflammation strongly contributes to the pathogenesis of pain. The clinical challenge of chronic pain relief led to the identification of molecules such as cytokines, chemokines and more recentl...
