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Article
Open AccessFive-Time Sit-To-Stand Lower Limb Muscle Power in Older Women: An Explorative, Descriptive and Comparative Analysis
Muscle power assessment entails the use of complex equipment which impacts its clinical applicability. Recently, equations to estimate lower-limb muscle power measures based on 5-repetition sit-to-stand (5STS)...
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Article
The Medium-Term Changes in Health-Related Behaviours among Spanish Older People Lifestyles during Covid-19 Lockdown
The aim was to evaluate general changes and investigate the association between diet quality, physical activity (PA), and sedentary time (ST) during COVID-19 lockdown and the subsequent 7-month changes in heal...
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Article
Factors associated with impairment in gait speed in older people with clinically normal gait. A cross-sectional study
Health professionals commonly use gait speed in the evaluation of functional status in older people. However, only a limited number of studies have assessed gait speed in the absence of disorders of gait, usin...
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Article
The Use of Posturography in Investigating the Risk of Falling in Frail or Prefrail Older People with Diabetes
In older people, diabetes is associated with an increased risk of falls and frailty. The value of using posturography for evaluating the risk of falling is unclear. In theory, a time-scale analysis should incr...
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Article
Open AccessPhysical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management
The task force of the International Conference of Frailty and Sarcopenia Research (ICFSR) developed these clinical practice guidelines to overview the current evidence-base and to provide recommendations for t...
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Article
Open AccessThe impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study
The medical morbidity and mortality associated with neck of femur fractures is well-documented, whereas there is limited data for patient-reported outcomes. The aim of this study was to characterize the impact...
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Article
Prevention of Disability in the Frail Chinese Older Population
As aging is becoming a global phenomenon, the burden of population aging is increasing rapidly, and is soon expected to be the highest in low-and middle-income countries. China represents the world’s largest p...
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Article
International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management
Sarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for ...
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Article
Key Messages for a Frailty Prevention and Management Policy in Europe from the Advantage Joint Action Consortium
In the 2015 Ageing Report, the European Commission (EC) and the Economic Policy Committee stated that co** with the challenge posed by an ageing population will require determined policy action in Europe, pa...
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Article
Global performance of executive function is predictor of risk of frailty and disability in older adults
The executive function is a complex set of skills affected during the aging process and translate into subclinical cerebrovascular disease. Postural instability or motor slowness are some clinical manifestatio...
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Article
Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity
Extracellular pre-B cell colony-enhancing factor/nicotinamide phosphoribosyltransferase/visfatin (ePBEF/NAMPT/visfatin) is an adipocytokine, whose circulating levels are enhanced in metabolic disorders, such a...
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Article
Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature
In a model of streptozotocin-induced Type 1 diabetes mellitus in rats of 9 weeks duration, we analysed time associations between the development of hyperglycaemia, early and intermediate glycosylation Amadori ...
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Article
Highly glycated oxyhaemoglobin impairs nitric oxide relaxations in human mesenteric microvessels
Aims/hypothesis. It has been recently shown that glycated human haemoglobin induces endothelial dysfunction in rat vessels by generating superoxide anions that interfere with nitric oxide mediate...
