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Article
Suizidstigma und Suizidprävention
In vielen Gesellschaften war und ist Suizid ein äußerst kontroverses Thema. Die vorliegende Übersichtsarbeit beschreibt die historischen Hintergründe gesellschaftlicher Verurteilung suizidaler Gedanken und Han...
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Article
Formation of the First Stars and Black Holes
We review the current status of knowledge concerning the early phases of star formation during cosmic dawn. This includes the first generations of stars forming in the lowest mass dark matter halos in which co...
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Article
Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease
Diabetes mellitus type 2 (2DM) is associated with altered bone quality. In order to analyze associated changes on a molecular level, we investigated the gene expression of key factors of osteoblast metabolism ...
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Article
Extended haplotype association study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3
The Ashkenazi Jewish population has a several-fold higher prevalence of Crohn’s disease (CD) compared with non-Jewish European ancestry populations and has a unique genetic history. Haplotype association is cr...
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Chapter and Conference Paper
Tidal Stirring of Milky Way Satellites: A Simple Picture with the Integrated Tidal Force
Most of dwarf spheroidal galaxies in the Local Group were probably formed via environmental processes like the tidal interaction with the Milky Way. We study this process via N-body simulations of dwarf galaxies ...
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Article
Direct formation of supermassive black holes via multi-scale gas inflows in galaxy mergers
Previously published models of supermassive black hole formation have struggled to explain the fact that — according to observations of distant quasars — supermassive black holes were already in place less tha...
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Article
Bulgeless dwarf galaxies and dark matter cores from supernova-driven outflows
Observations show most dwarf galaxies to be almost 'bulgeless', consisting of a rotating stellar disc embedded in a massive near-constant-density core halo of cold dark matter. This sits uncomfortably with the...
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Article
No evidence of association between a functional polymorphism in the MTHFR gene and childhood-onset mood disorders
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Article
Early gas strip** as the origin of the darkest galaxies in the Universe
Dwarf spheroidal galaxies are dominated by dark matter, and within their ranks Draco, Ursa Minor and Andromeda X are 'darkest'. None of the models so far proposed to explain their formation can account for bot...
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Chapter and Conference Paper
Multi-Scale Simulations of Merging Galaxies with Supermassive Black Holes
We present the results of the first multi-scale N-body+hydrodynamical simulations of merging galaxies containing central supermassive black holes (SMBHs) and having a spatial resolution of only a few parsecs. ...
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Chapter and Conference Paper
The Effect of Gaseous Dissipation on the Fate of Supermassive Black Holes in Merging Galaxies
We analyze the effect of dissipation on the orbital evolution of supermassive black holes (SMBHs) using high-resolution gasdynamical simulations of binary equal- and unequal-mass mergers of disk dominated gala...
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Chapter
Inflammatory bowel disease: autoimmunity or chronic inflammation?
The current concepts of autoimmunity have gone beyond the initial descriptions of autoantibodies. The nature of an autoreactive immune response must result in an organ-specific inflammatory reaction — e.g. pat...
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Article
Perinuclear anti-neutrophil cytoplasmic antibody and refractory pouchitis
Refractory pouchitis (RP) is a debilitating complication of ileal pouch reservoirs that affects hypothesized that it reflects underlying Crohn's disease. Since perinuclear anti-neutrophil cytoplasmic antibody ...
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Chapter
Antigen handling in the intestine mediated by normal enterocytes
The co-existence of a myriad of foreign antigens in the intestinal lumen alongside immunocompetent cells has resulted in the evolution of a specialized mucosal immune system. A natural physical barrier to anti...
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Chapter
The Role of Epithelial Cells as Accessory Cells
Mucosal immunity is characterized by poor or absent responses to most orally administered antigens (1,2). Antigens access into gut-associated lymphoid tissues (GALT) is partially inhibited by a mucous coat con...
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Chapter
Switch T Cell Line, ST, Induces an Ig Class Switch in Surface Isotype
We have previously demonstrated that T cells, Trac, isolated from a patient with Sezary’s/mycosis fungoides was capable of inducing an Ig class switch in B cells derived from patients with immunodeficiency and...
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Article
T-cell subsets in multiple sclerosis: Lack of correlation between helper and suppressor T cells and the clinical state
Peripheral blood T-lymphocyte subsets were investigated in a group of 26 multiple sclerosis (MS) patients of different clinical categories and compared to those of 15 normal controls and 7 other patients with ...
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Article
The importance of cavity roosting and hypothermia to the energy balance of the winter acclimatized Carolina chickadee
Noctural hypothermia and cavity roosting account for a significant reduction in energy expenditure in winter acclimatized Carolina chickadees. As much as 10‡C hypothermia amounted to a 33.0% reduction in metab...
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Article
Verbesserung der gestörten Glukoseverwertung durch Bradykinin bei Diabetikern und bei Patienten im postoperativen Streß
Intravenous glucose tolerance tests (GTT) were performed in 13 metabolically healthy patients at the first and second day after abdominal surgery. GTT were carried out during an additional infusion of bradykin...
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Article
Sulphydryl requirement for insulin release from the perfused pancreas
Using the isolated, perfused rat pancreas the importance of sulphydryl groups for the secretory process of insulin was investigated. It was found that ethacrynic acid (EA, 0.075–0.6 mmol/1) caused a dose-depen...
