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  1. Article

    Open Access

    The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells

    Inhibitor-of-apoptosis protein (IAP) inhibitors have been reported to synergistically reduce cell viability in combination with a variety of chemotherapeutic drugs via targeted cellular IAP (cIAP) depletion. H...

    P Wu, K J Shi, J J An, Y L Ci, F Li, K Y Hui, Y Yang, C M Xu in Cell Death & Disease (2014)

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  2. Article

    Open Access

    The ROS/JNK/ATF2 pathway mediates selenite-induced leukemia NB4 cell cycle arrest and apoptosis in vitro and in vivo

    It has previously been shown that selenite can act as an antitumor agent and inhibit cancer cell growth, although the mechanism responsible for this effect is not well understood. In this study, we have shown ...

    J J An, K J Shi, W Wei, F Y Hua, Y L Ci, Q Jiang, F Li, P Wu… in Cell Death & Disease (2013)

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  3. No Access

    Article

    Extended haplotype association study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3

    The Ashkenazi Jewish population has a several-fold higher prevalence of Crohn’s disease (CD) compared with non-Jewish European ancestry populations and has a unique genetic history. Haplotype association is cr...

    W Zhang, K Y Hui, A Gusev, N Warner, S M E Ng, J Ferguson, M Choi… in Genes & Immunity (2013)