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  1. Article

    Open Access

    BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families

    Worldwide variation in the distribution of BRCA1 and BRCA2 mutations is well recognised, and for the Belgian population no comprehensive studies about BRCA1/2 mutation spectra or frequencies have been published. ...

    K Claes, B Poppe, I Coene, A De Paepe, L Messiaen in British Journal of Cancer (2004)

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  2. Article

    Open Access

    Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

    The chromosomal radiosensitivity of breast cancer patients with a known or putative genetic predisposition was investigated and compared to a group of healthy women. The chromosomal radiosensitivity was assess...

    A Baeyens, H Thierens, K Claes, B Poppe, L Messiaen… in British Journal of Cancer (2002)

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  3. No Access

    Article

    Characterisation of two different nonsense mutations, C6792A and C6792G, causing skip** of exon 37 in the NF1 gene

    Neurofibromatosis type 1 (NF1), characterised by peripheral neurofibromas, café-au-lait spots and iris Lisch nodules, is one of the most common inherited disorders. We have analysed exons 35 to 49 in 21 unrel...

    L. Messiaen, Tom Callens, A. De Paepe, Margarita Craen, Geert Mortier in Human Genetics (1997)

  4. No Access

    Article

    Anin vitro model for chick embryonic notochords

    A two step method to obtain mesenchymal free 3.5 day old chick embryonic notochordsin vitro is presented. 1.) Notochords are isolated by mechanical microdissection from the embryos below the head and above the le...

    E. Ghanem, L. Messiaen, L. De Ridder in Cytotechnology (1995)

  5. No Access

    Article

    Spontaneous acquisition of tumorigenicity and invasiveness by mouse lens explant cells during culture in vitro

    The lens of the eye is one of the rare organs in which tumors do not occur spontaneously. It therefore appeared to us that lens cells would not present the background of spontaneous transformation toward malig...

    L. Messiaen, S. Qian, G. De Bruyne… in In Vitro Cellular & Developmental Biology … (1991)

  6. No Access

    Chapter and Conference Paper

    Correlations of Malignancy in Cultured Cells

    Normal tissues are under strict growth control (G- phenotype). Benign tumours differ from normal tissues by loss of growth control (G+ phenotype), but they are not invasive (I- phenotype) and not metastatic (M- p...

    M. M. Mareel, F. M. Van Roy, L. Messiaen, N. Van Larebeke… in New Frontiers in Cytology (1988)

  7. No Access

    Article

    Late abstracts 186–187

    J. Jaehne, H. -J. Meyer, Ch. Wittekind, H. Maschek… in Clinical & Experimental Metastasis (1988)

  8. No Access

    Chapter

    Investigation of Tumour-Invasion Mechanisms

    Methods currently used in our laboratories to analyze the invasive and metastatic capabilities of cell populations in vitro and in vivo are as follows: confrontation of cell clusters or cellular aggregates with f...

    M. Mareel, F. Van Roy, L. Messiaen… in Cells, Membranes, and Disease, Including R… (1987)