Abstract
Normal tissues are under strict growth control (G- phenotype). Benign tumours differ from normal tissues by loss of growth control (G+ phenotype), but they are not invasive (I- phenotype) and not metastatic (M- phenotype). Malignant tumours also display the G+ phenotype, but at least part of their cell populations have acquired invasive (I+ phenotype) and metastatic (M+ phenotype) capabilities. We infer from these well-documented clinical and pathological observations that invasion and metastasis, more than loss of growth control, are the hallmarks of malignancy. Obviously, this does not mean that uncontrolled growth does not contribute to the progression of the disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Behrens J, Mareel MM, Van Roy FM, Birchmeier W. Essential steps in tumor cell invasion: epithelial cells acquire invasive properties following the loss of uvomorulin-mediated cell-cell adhesion (to be published)
Bracke ME, Van Cauwenberge RM-L, Mareel MM (1984) ( + )-Catechin inhibits the invasion of malignant fibrosarcoma cells into chick heart in vitro. Clin Exp Metastasis 2:161–170
De Baetselier P, Roos E, Brys L, Remels L, Feldman M (1984) Generation of invasive and metastatic variants of a non-metastatic T-cell lymphoma by in vivo fusion with normal host cells. Int J Cancer 34: 731–738
De Potter C, Pauwels C, Beghin C, Praet M, Mareel M, Roels H (to be published) The expression of p21-røs proteins in human neoplastic and non-neoplastic breast tissue, (to be published)
Distelmans W, Van Gynckel R, Vanherck W, De Brabander M (1985) The kidney invasion test: an assay allowing macroscopic quantification of malignant invasion in vivo. Invasion Metastasis 5: 170–184
Mareel MM, Van Roy FM (1986) Are oncogenes involved in invasion and metastasis? Anticancer Res 6: 419–436
Mareel MM, Bruyneel EA, De Bruyne GK, Dragonetti CH, Van Cauwenberge RM-L (1982) Growth and invasion: separate activities of malignant MO4 cell populations in vitro. In: Galeotti T, Cittadini A, Neri G, Papa S (eds) Membranes in Tumour Growth. Elsevier, pp 223–232
Mareel MM, Bruyneel EA, Dragonetti CH, De Bruyne GK, Van Cauwenberge RM-L, Smets LA, Van Rooy H (1984) Effect of temperature on invasion of MO4 mouse fibrosarcoma cells in organ culture. Clin Exp Metastasiss 2:107–125
Mareel MM, De Bruyne GK, Sonnenberg A, Hilgers J (1986) Experimental results on invasiveness of mouse mammary cells: clinical implications? In: Hollmann KH, Verley JM (eds) New frontiers in mammary pathology 1986. Nijhoff, Boston, pp 351–362
Mareel MM, Van Roy FM, Messiaen LM, Boghaert ER, Bruyneel EA (1987) Qualitative and quantitative analysis of tumour invasion in vivo and in vitro. J Cell Sci Suppl 8: 141–163
Nicolson GL, Poste G (1983) Tumor cell diversity and host response in cancer metastasis part II: host immune responses and therapy of metastases. Curr Probl Cancer 7: 3–42
Poste G, Greig R (1982) On the genesis and regulation of cellular heterogeneity in malignant tumors. Invasion Metastasis 2:137–176
Sonnenberg A, Daams H, Calafat J, Hilgers J (1986) In vitro differentiation and progression of mouse mammary tumor cells. Cancer Res 46: 5913–5922
Storme GA, Berdel WE, van Blitterswijk WJ, Bruyneel EA, De Bruyne GK, Mareel MM (1985) Antiinvasive effect of racemic l-0-octadecyl-2-0-methyl glycero-3-phosphocholine (ET-I8-OCH3) on MO4 mouse fibrosarcoma cells in vitro. Cancer Res 45: 351–357
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Mareel, M.M., Van Roy, F.M., Messiaen, L., Van Larebeke, N., Boghaert, E. (1988). Correlations of Malignancy in Cultured Cells. In: Goerttler, K., Feichter, G.E., Witte, S. (eds) New Frontiers in Cytology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73596-7_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-73596-7_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73598-1
Online ISBN: 978-3-642-73596-7
eBook Packages: Springer Book Archive