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Article
Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis
Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfo...
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Article
Open AccessIncreased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas
Cell cultures of ovarian cystadenomas transfected with SV40 large T antigen are not immortal because they invariably reach a phenomenon called crisis, which is triggered in part by telomere attrition. Recovery...
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Article
Open AccessThe receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome
EphB4 is a member of the largest family of transmembrane receptor tyrosine kinases and plays critical roles in axonal pathfinding and blood vessel maturation. We wanted to determine the biological role of EphB...
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Article
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors
How hypermethylation and hypomethylation of different parts of the genome in cancer are related to each other and to DNA methyltransferase (DNMT) gene expression is ill defined. We used ovarian epithelial tumo...
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Article
Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis
We compared global levels of DNA methylation as well as methylation of a specific locus (MyoD1) in ovarian cystadenomas, ovarian tumours of low malignant potential (LMP) and ovarian carcinomas to investigate t...
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Article
WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer
Mutations in the WAF1/CIP1 gene were not found in 36 ovarian carcinomas, including tumours with loss of heterozygosity at the WAF1/CIP1 locus and/or lacking p53 mutations. In addition, no association was demon...
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New insights into the genetics of human ovarian epithelial tumor development
Much progress was made during the last decade toward the identification and characterization of several of the genetic determinants of carcinogenesis. The actual mechanisms of tumorigenesis remain largely unkn...
