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  1. No Access

    Article

    Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

    S Chen, R Gao, C Yao, M Kobayashi, S Z Liu, M C Yoder, H Broxmeyer, R Kapur… in Leukemia (2018)

  2. Article

    ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

    ΔNp63α, implicated as an oncogene, is upregulated by activated Akt, part of a well-known cell survival pathway. Inhibition of Akt activation by phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and t...

    M K Leonard, R Kommagani, V Payal, L D Mayo, H N Shamma… in Cell Death & Differentiation (2011)

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  3. No Access

    Article

    ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability

    Secretory clusterin (sCLU) is a stress-induced, pro-survival glycoprotein elevated in early-stage cancers, in particular in APC/Min-defective colon cancers. sCLU is upregulated after exposure to various cytoto...

    E M Goetz, B Shankar, Y Zou, J C Morales, X Luo, S Araki, R Bachoo, L D Mayo… in Oncogene (2011)

  4. Article

    Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

    Earlier, we have reported that 70 kDa subunit of Ku protein heterodimer (Ku70) binds and inhibits Bax activity in the cytosol and that ubiquitin (Ub)-dependent proteolysis of cytosolic Ku70 facilitates Bax-med...

    V Gama, J A Gomez, L D Mayo, M W Jackson, D Danielpour… in Cell Death & Differentiation (2009)

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