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  1. Article

    Open Access

    AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo

    The cytidine analogue, 5-azacytidine (AZA; 5-AZA-cR), is the primary treatment for myelodysplastic syndrome and chronic myelomonocytic leukaemia. However, only ~50% of treated patients will respond to AZA and ...

    A Unnikrishnan, A N Q Vo, R Pickford, M J Raftery, A C Nunez, A Verma… in Leukemia (2018)

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  2. Article

    Open Access

    Morphological and proteomic analysis of biofilms from the Antarctic archaeon, Halorubrum lacusprofundi

    Biofilms enhance rates of gene exchange, access to specific nutrients, and cell survivability. Haloarchaea in Deep Lake, Antarctica, are characterized by high rates of intergenera gene exchange, metabolic spec...

    Y. Liao, T. J. Williams, J. Ye, J. Charlesworth, B. P. Burns… in Scientific Reports (2016)

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  3. Article

    Open Access

    Quantitative proteomics of delirium cerebrospinal fluid

    Delirium is a common cause and complication of hospitalization in older people, being associated with higher risk of future dementia and progression of existing dementia. However relatively little data are ava...

    A Poljak, M Hill, R J Hall, A M MacLullich, M J Raftery, J Tai… in Translational Psychiatry (2014)

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  4. Article

    Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

    We examined the time-dependent effects of deletion of the gene encoding protein kinase C epsilon (Prkce) on glucose homeostasis, insulin secretion and hepatic lipid metabolism in fat-fed mice.

    K. Raddatz, N. Turner, G. Frangioudakis, B. M. Liao, D. J. Pedersen… in Diabetologia (2011)

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  5. No Access

    Article

    αB-Crystallin is a major component of glial cytoplasmic inclusions in multiple system atrophy

    Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of α-synuclein filaments. αB-crystallin, a small chaperone protein that binds to unf...

    D. L. Pountney, T. M. Treweek, T. Chataway, Y. Huang, F. Chegini… in Neurotoxicity Research (2005)

  6. No Access

    Article

    Successful transplantation of kidneys bearing previously mismatched HLA A and B locus antigens

    Transplantation of kidneys bearing HLA antigens to which recipients have previously been exposed is generally avoided, and such prudence is a well-documented means of preventing early graft loss. Prior exposur...

    K. I. Welsh, M. van Dam, M. E. Bewick, G. K. Koffman… in Transplant International (1988)