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Article
Open AccessEffect of hormone-induced plasma membrane phosphatidylinositol 4,5-bisphosphate depletion on receptor endocytosis suggests the importance of local regulation in phosphoinositide signaling
Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to be critical for the endocytosis of G protein-coupled receptors (GPCRs). We have previously demonstrated that depletion of PIP2 by chemically induc...
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Article
Open AccessPharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells
Immunolabeling and autoradiography have traditionally been applied as the methods-of-choice to visualize and collect molecular information about physiological and pathological processes. Here, we introduce Pha...
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Protocol
Development of Nonspecific BRET-Based Biosensors to Monitor Plasma Membrane Inositol Lipids in Living Cells
There are several difficulties to face when investigating the role of phosphoinositides. Although they are present in most organelles, their concentration is very low, sometimes undetectable with the available...
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Chapter
Nephrogenic Diabetes Insipidus
Body fluid homeostasis is essential for normal life. In the maintenance of water balance, the most important factor and regulated process is the excretory function of the kidneys. The kidneys are capable to co...
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Article
Open AccessInvestigation of the PtdIns(4,5)P2 dependence of plasma membrane receptor endocytosis in living cells
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Article
Open AccessCharacterization of different G protein coupling properties of CB1 and CB2 cannabinoid receptors and GPR55 receptor using BRET
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Article
Open AccessTransactivation within the AT1 angiotensin receptor homodimer: the role of the conserved DRY motif
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Article
Unusual presentation of multiple endocrine neoplasia type 1 in a young woman with a novel mutation of the MEN1 gene
We report an unusual presentation of multiple endocrine neoplasia type 1 (MEN 1) in a young woman who was subsequently proven to have a novel mutation of the MEN1 gene. The young patient, aged 25 years, was inves...
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Article
Hungary: basic science needs European support
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Article
Second messengers derived from inositol lipids
Many hormones, growth factors, and neurotransmitters stimulate their target cells by promoting the hydrolysis of plasma-membrane phosphoinositides to form the two second messengers, diacylglycerol and inositol...
